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Klp98A Kinesin-like protein at 98A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43310, updated on 9-Dec-2024

Summary

Official Symbol
Klp98Aprovided by FlyBase
Official Full Name
Kinesin-like protein at 98Aprovided by FlyBase
Primary source
FLYBASE:FBgn0004387
Locus tag
Dmel_CG5658
See related
AllianceGenome:FB:FBgn0004387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5658; Dmel\CG5658; DmKlp98A; DmSNX23; KIF 16A; KIF16A/B; Klp6; KLP6; klp98A; Klp98a; KLP98A; Snx23
Summary
Enables phosphatidylinositol-3-phosphate binding activity and plus-end-directed microtubule motor activity. Involved in asymmetric protein localization involved in cell fate determination; plus-end-directed endosome transport along mitotic spindle midzone microtubule; and transcytosis. Colocalizes with early endosome. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Klp98A in Genome Data Viewer
Location:
98A4-98A6; 3-94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27547775..27559145, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23373497..23384867, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 98c Neighboring gene Gustatory receptor 98d Neighboring gene small non-coding RNA 157 Neighboring gene uncharacterized protein Neighboring gene widerborst

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables microtubule binding  
enables microtubule binding  
enables microtubule motor activity  
enables phosphatidylinositol binding  
enables phosphatidylinositol phosphate binding  
enables phosphatidylinositol-3-phosphate binding PubMed 
enables plus-end-directed microtubule motor activity  
enables plus-end-directed microtubule motor activity PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
colocalizes_with early endosome PubMed 
colocalizes_with endosome  
part_of kinesin complex  
is_active_in microtubule  

General protein information

Preferred Names
Kinesin-like protein at 98A
Names
CG5658-PA
CG5658-PB
Kinesin7B
Klp98A-PA
Klp98A-PB
NP_001247339.1
NP_524532.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27547775..27559145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260410.2 → NP_001247339.1  Kinesin-like protein at 98A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VB25
    Conserved Domains (6) summary
    cd06874
    Location:1090 → 1218
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 371
    KISc; Kinesin motor, catalytic domain. ATPase
    COG5134
    Location:606 → 768
    COG5134; Uncharacterized conserved protein [Function unknown]
    cd00060
    Location:456 → 555
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 371
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:370 → 478
    Kinesin_assoc; Kinesin-associated
  2. NM_079808.4 → NP_524532.2  Kinesin-like protein at 98A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524532.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4K7N6, Q00088, Q8SZH6, Q9VB25
    Related
    FBpp0084581
    Conserved Domains (5) summary
    cd06874
    Location:1131 → 1259
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 371
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:456 → 555
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:2 → 371
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam16183
    Location:370 → 478
    Kinesin_assoc; Kinesin-associated
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