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Mtl Mig-2-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43319, updated on 9-Dec-2024

Summary

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Official Symbol
Mtlprovided by FlyBase
Official Full Name
Mig-2-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0039532
Locus tag
Dmel_CG5588
See related
AllianceGenome:FB:FBgn0039532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5588; CG5588; Dmel\CG5588; dMig-2; Mt1/Mig2-like; mtl; MTL; Rac; Rac GTPase; Rac-like; Rac3
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; establishment of planar polarity; and hemocyte migration. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Mtl in Genome Data Viewer
Location:
98A13-98A13; 3-94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27636412..27639871)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23462134..23465593)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tusp Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-1001 stem loop Neighboring gene tau Neighboring gene Ribosomal protein S10a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye. Muñoz-Soriano V, et al. Fly (Austin), 2011 Apr-Jun. PMID 21441778
  2. Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase. Yang X, et al. J Genet Genomics, 2024 Apr. PMID 38049063
  3. Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Bosch DE, et al. Structure, 2013 Jan 8. PMID 23260656, Free PMC Article
  4. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration. Lei F, et al. PLoS One, 2023. PMID 36662713, Free PMC Article
  5. Rac function and regulation during Drosophila development. Hakeda-Suzuki S, et al. Nature, 2002 Mar 28. PMID 11919634

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure, elongation of leading edge cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of imaginal disc-derived wing hair orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of ommatidial planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesodermal cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of wound healing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mig-2-like
Names
CG5588-PA
CG5588-PB
CG5588-PC
Mtl(Rac-like)
Mtl-PA
Mtl-PB
Mtl-PC
Rac
Rac GTPase
mig-2-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27636412..27639871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170344.2 → NP_733223.1  Mig-2-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWS8
    Related
    FBpp0084561
    Conserved Domains (1) summary
    smart00174
    Location:9 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

  2. NM_079809.3 → NP_524533.1  Mig-2-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWS8
    Related
    FBpp0084562
    Conserved Domains (1) summary
    smart00174
    Location:9 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

  3. NM_170343.2 → NP_733222.1  Mig-2-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWS8
    Related
    FBpp0084563
    Conserved Domains (1) summary
    smart00174
    Location:9 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWS8 Q7JWS8

Gene LinkOut

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