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Sce Sex combs extra [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43327, updated on 4-Jan-2025

Summary

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Official Symbol
Sceprovided by FlyBase
Official Full Name
Sex combs extraprovided by FlyBase
Primary source
FLYBASE:FBgn0003330
Locus tag
Dmel_CG5595
See related
AllianceGenome:FB:FBgn0003330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5595; Ding; Dmel\CG5595; dring; dRing; dRING; Dring; DRING; dRing1; dRING1; dRNIG; Ring; RING; Ring/Sce; RING/Sce; RING1; Rnf2; sce; SCE; Sce/dRing; See/dRing
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including anterior/posterior axis specification; follicle cell of egg chamber development; and regulation of gene expression. Located in chromatin; nuclear envelope; and nucleolus. Part of PRC1 complex. Is expressed in several structures, including antennal primordium; anterior endoderm anlage; central brain primordium; ganglia; and head epidermis primordium. Used to study Luo-Schoch-Yamamoto syndrome and cancer. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to several human genes including RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sce in Genome Data Viewer
Location:
98B1-98B1; 3-94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27680431..27682029, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23506153..23507751, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hydroxysteroid dehydrogenase like 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. Yang L, et al. Nat Commun, 2019 May 21. PMID 31113955, Free PMC Article
  2. A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion. Balicky EM, et al. Chromosoma, 2004 Feb. PMID 14669021
  3. Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features. Luo X, et al. Hum Mol Genet, 2021 Jun 26. PMID 33864376, Free PMC Article
  4. Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster. Sharp EJ, et al. Dev Biol, 1994 Feb. PMID 8313990
  5. Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Loubière V, et al. Nat Genet, 2016 Nov. PMID 27643538, Free PMC Article

See all (233) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fsh physically interacts with Pc-Sce complex.Sce is required for Ci transcription
    Title: Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci).
  2. SCE, together with dRYBP, inhibits apoptosis either by epigenetically regulating Dp53 transcription or by controlling the stabilization of DP53 protein levels thus promoting its ubiquitylation for proteaosomal degradation.
    Title: Drosophila SCE/dRING E3-ligase inhibits apoptosis in a Dp53 dependent manner.
  3. Sce synergizes with the Polycomb repressive deubiquitinase complex to repress transcription at class I genes, suggesting that H2A monoubiquitylation must be appropriately balanced for their transcriptional repression.
    Title: The role of the histone H2A ubiquitinase Sce in Polycomb repression.
  4. a novel role for protein dRING; promotes the proper segregation of meiotic chromosomes
    Title: A proposed role for the Polycomb group protein dRING in meiotic sister-chromatid cohesion.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in follicle cell of egg chamber stalk formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived female germ-line cyst encapsulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sex combs extra
Names
CG5595-PA
SCE/dRING
Sce-PA
Sex comb extra
dRING1
ring

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27680431..27682029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058161.4 → NP_477509.1  Sex combs extra [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477509.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18380, Q9VB08
    Related
    FBpp0084614
    Conserved Domains (2) summary
    cd00162
    Location:45 → 89
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam16207
    Location:336 → 431
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB08.1 Q9VB08

Gene LinkOut

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