CG4849 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG4849provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0039566
Locus tag: Dmel_CG4849
See related: AllianceGenome:FB:FBgn0039566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG4849; eEF2; eftud2; EFTUD2; Snu114
Summary: Predicted to enable GTPase activity; U5 snRNA binding activity; and translation elongation factor activity. Involved in positive regulation of gene expression. Located in cytoplasm. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in esophageal atresia; hepatitis B; hepatocellular carcinoma; mandibulofacial dysostosis, Guion-Almeida type; and microcephaly. Orthologous to human EFTUD2 (elongation factor Tu GTP binding domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (27963415..27966958)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (23789137..23792680)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables U5 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational elongation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of U2-type catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
part_of small nuclear ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of small nuclear ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain