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Gfat2 Glutamine:fructose-6-phosphate aminotransferase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43373, updated on 4-Jan-2025

Summary

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Official Symbol
Gfat2provided by FlyBase
Official Full Name
Glutamine:fructose-6-phosphate aminotransferase 2provided by FlyBase
Primary source
FLYBASE:FBgn0039580
Locus tag
Dmel_CG1345
See related
AllianceGenome:FB:FBgn0039580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1345; Dmel/GFAT2; Dmel\CG1345; gfat2; GFAT2
Summary
Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in UDP-N-acetylglucosamine biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including GFPT2 (glutamine-fructose-6-phosphate transaminase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gfat2 in Genome Data Viewer
Location:
98C4-98C4; 3-95 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28337019..28339765, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24162741..24165487, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene La related protein Neighboring gene antisense RNA:CR46104 Neighboring gene antisense RNA:CR46105 Neighboring gene Moca-cyp Neighboring gene Odorant receptor 98b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner. Graack HR, et al. Biochem J, 2001 Dec 1. PMID 11716769, Free PMC Article
  2. Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions. Chen P, et al. Fly (Austin), 2020 Mar-Dec. PMID 32615907, Free PMC Article
  3. Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Niccoli T, et al. Curr Biol, 2016 Sep 12. PMID 27524482, Free PMC Article
  4. Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals. Liu X, et al. J Biol Chem, 2024 Feb. PMID 38159854, Free PMC Article
  5. New local potential useful for genome annotation and 3D modeling. Chandonia JM, et al. J Mol Biol, 2003 Sep 26. PMID 12972255

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
    Title: Drosophila GFAT1 and GFAT2 enzymes encode obligate developmental functions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate derivative biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Glutamine:fructose-6-phosphate aminotransferase 2
Names
CG1345-PA
Gfat2-PA
glucose-fructose amidotransferase 2
NP_651617.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28337019..28339765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143360.4 → NP_651617.1  Glutamine:fructose-6-phosphate aminotransferase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651617.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAW3
    Related
    FBpp0084666
    Conserved Domains (4) summary
    PLN02981
    Location:1 → 683
    PLN02981; glucosamine:fructose-6-phosphate aminotransferase
    cd00714
    Location:2 → 285
    GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
    cd05008
    Location:370 → 495
    SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
    cd05009
    Location:528 → 681
    SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAW3 Q9VAW3

Gene LinkOut

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