U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nepl20 Neprilysin-like 20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43412, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Nepl20provided by FlyBase
Official Full Name
Neprilysin-like 20provided by FlyBase
Primary source
FLYBASE:FBgn0039613
Locus tag
Dmel_CG14527
See related
AllianceGenome:FB:FBgn0039613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14527; Dmel\CG14527
Summary
Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nepl20 in Genome Data Viewer
Location:
98F1-98F1; 3-97 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28880792..28882945)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24706514..24708667)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 18 Neighboring gene Neprilysin-like 19 Neighboring gene Neprilysin-like 21 Neighboring gene Darkener of apricot

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Modulated modularity clustering as an exploratory tool for functional genomic inference. Stone EA, et al. PLoS Genet, 2009 May. PMID 19424432, Free PMC Article
  2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  4. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article
  5. Mating induces an immune response and developmental switch in the Drosophila oviduct. Kapelnikov A, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18725632, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Neprilysin-like 20
Names
CG14527-PA
Nepl20-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28880792..28882945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143388.2 → NP_651645.1  Neprilysin-like 20 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKJ2, Q9VAS0
    Related
    FBpp0084699
    Conserved Domains (2) summary
    cd08662
    Location:56 → 697
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:50 → 691
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAS0 Q9VAS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous