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DIP-gamma Dpr-interacting protein gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43417, updated on 4-Jan-2025

Summary

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Official Symbol
DIP-gammaprovided by FlyBase
Official Full Name
Dpr-interacting protein gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0039617
Locus tag
Dmel_CG14521
See related
AllianceGenome:FB:FBgn0039617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
14521; anon-WO0140519.196; CG14521; CT34248; DIPgamma; Dmel\CG14521
Summary
Involved in establishment of synaptic specificity at neuromuscular junction; photoreceptor cell axon guidance; and regulation of neuromuscular junction development. Located in neuron projection membrane. Is expressed in several structures, including adult head; ganglia; lobula plate tangential neurons; medulla layer; and optic lobe intrinsic neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See DIP-gamma in Genome Data Viewer
Location:
98F2-98F4; 3-97 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28925004..28970372, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24750726..24796094, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 21 Neighboring gene Darkener of apricot Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45669 Neighboring gene waterproof Neighboring gene mir-4947 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners. Xu C, et al. Neuron, 2019 Sep 4. PMID 31300277, Free PMC Article
  2. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Sancer G, et al. Arthropod Struct Dev, 2021 Mar. PMID 33618155
  3. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article
  4. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
  5. Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits. Menon KP, et al. Elife, 2019 Nov 6. PMID 31692445, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions between Dpr11 and DIP-gamma control selection of amacrine neurons in Drosophila color vision circuits.
    Title: Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits.
  2. study provides evidence that DIPgamma in yDm8 neurons and Dpr11 in yR7 photpreceptors instruct synaptic partner matching
    Title: Coordination between stochastic and deterministic specification in the Drosophila visual system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in establishment of synaptic specificity at neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Dpr-interacting protein gamma
Names
CG14521-PA
DIP-gamma-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28925004..28970372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143392.3 → NP_651649.1  Dpr-interacting protein gamma [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAR6
    Related
    FBpp0084716
    Conserved Domains (2) summary
    smart00410
    Location:247 → 355
    IG_like; Immunoglobulin like
    cl11960
    Location:140 → 238
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAR6 Q9VAR6

Gene LinkOut

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