eIF4E6 eukaryotic translation initiation factor 4E6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF4E6provided by FlyBase
Official Full Name: eukaryotic translation initiation factor 4E6provided by FlyBase
Primary source: FLYBASE:FBgn0039622
Locus tag: Dmel_CG1442
See related: AllianceGenome:FB:FBgn0039622
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH55324; CG1442; Dmel\CG1442; eIF4E; eIF4E-6
Summary: Enables RNA 7-methylguanosine cap binding activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29026439..29027174, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24852161..24852896, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT enables eukaryotic initiation factor 4G binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables translation repressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of translation	TAS Traceable Author Statement more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG1442-PA; CG1442-PB; CG1442-PC; eIF4E-6; eIF4E6-PA; eIF4E6-PB; eIF4E6-PC

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The following sections contain reference sequences that belong to a specific genome build. Explain