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CG11843 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43432, updated on 9-Dec-2024

Summary

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Official Symbol
CG11843provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039630
Locus tag
Dmel_CG11843
See related
AllianceGenome:FB:FBgn0039630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG11843; SP43
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG11843 in Genome Data Viewer
Location:
98F6-98F6; 3-97 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29054347..29055837)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24880069..24881559)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46107 Neighboring gene Sirtuin 7 Neighboring gene Cullin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Rossi F, et al. Open Biol, 2017 Aug. PMID 28855394, Free PMC Article
  2. Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis. Zhu L, et al. RNA Biol, 2019 Oct. PMID 31195914, Free PMC Article
  3. During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay. Katsuyama T, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25902518, Free PMC Article
  4. A genome-wide analysis of immune responses in Drosophila. Irving P, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742098, Free PMC Article
  5. Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. Buffin E, et al. PLoS One, 2010 Feb 19. PMID 20174573, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11843-PA
CG11843-PB
NP_001287578.1
NP_651663.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29054347..29055837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300649.1 → NP_001287578.1  uncharacterized protein Dmel_CG11843, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287578.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0P8M2, Q9VAQ2
    Conserved Domains (2) summary
    smart00020
    Location:68 → 309
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:68 → 312
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_143406.2 → NP_651663.1  uncharacterized protein Dmel_CG11843, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0P8M2, Q9VAQ2
    Related
    FBpp0084732
    Conserved Domains (2) summary
    smart00020
    Location:68 → 309
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:68 → 312
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAQ2 Q9VAQ2

Gene LinkOut

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