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dgt6 dim gamma-tubulin 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43441, updated on 4-Jan-2025

Summary

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Official Symbol
dgt6provided by FlyBase
Official Full Name
dim gamma-tubulin 6provided by FlyBase
Primary source
FLYBASE:FBgn0039638
Locus tag
Dmel_CG11881
See related
AllianceGenome:FB:FBgn0039638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11881; Dgt6; Dmel\CG11881; msd4
Summary
Enables protein-macromolecule adaptor activity. Involved in microtubule cytoskeleton organization and regulation of mitotic nuclear division. Located in spindle. Part of HAUS complex. Is expressed in organism. Orthologous to human HAUS6 (HAUS augmin like complex subunit 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See dgt6 in Genome Data Viewer
Location:
98F12-98F12; 3-97 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29128584..29130972, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24954306..24956694, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Autophagy-related 14 Neighboring gene yemanuclein Neighboring gene Choline transporter-like 2 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Suppressor of ER stress-induced death Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation. Vernì F, et al. Cell Cycle, 2015. PMID 25591068, Free PMC Article
  2. Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle. Ito A, et al. J Cell Biol, 2015 Dec 7. PMID 26644514, Free PMC Article
  3. The role of Patronin in Drosophila mitosis. Pavlova GA, et al. BMC Mol Cell Biol, 2019 Apr 17. PMID 31284878, Free PMC Article
  4. Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes. Colombié N, et al. PLoS Genet, 2013 Jun. PMID 23785300, Free PMC Article
  5. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. Bouissou A, et al. EMBO J, 2014 Jan 13. PMID 24421324, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IC
Inferred by Curator
more info
 PubMed 
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle-templated microtubule nucleation IC
Inferred by Curator
more info
 PubMed 
involved_in mitotic spindle-templated microtubule nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of HAUS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HAUS complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitotic spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dim gamma-tubulin 6
Names
CG11881-PA
dgt6-PA
mitotic spindle density 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29128584..29130972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143414.4 → NP_651671.1  dim gamma-tubulin 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651671.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAP2
    Related
    FBpp0084783
    Conserved Domains (1) summary
    pfam14661
    Location:21 → 257
    HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAP2.1 Q9VAP2

Gene LinkOut

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