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Vha100-1 Vacuolar H[+] ATPase 100kD subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43442, updated on 9-Dec-2024

Summary

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Official Symbol
Vha100-1provided by FlyBase
Official Full Name
Vacuolar H[+] ATPase 100kD subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0028671
Locus tag
Dmel_CG1709
See related
AllianceGenome:FB:FBgn0028671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21248; CG1709; Dmel\CG1709; V0; V0a; v0a1; v100; V100; V100-1; vha; Vha100; vha100-1
Summary
Enables calmodulin binding activity and photoreceptor activity. Involved in several processes, including autophagosome maturation; intracellular pH reduction; and terminal branching, open tracheal system. Located in early endosome and synaptic vesicle. Is expressed in several structures, including adult head; adult heart; adult midgut; embryonic/larval garland cell; and ganglia. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; and renal tubular acidosis. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vha100-1 in Genome Data Viewer
Location:
98F12-98F12; 3-97 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29131193..29137980)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24956915..24963702)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Choline transporter-like 2 Neighboring gene dim gamma-tubulin 6 Neighboring gene Suppressor of ER stress-induced death Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new view of an old pore. Bajjalieh S. Cell, 2005 May 20. PMID 15907459
  2. On the role of v-ATPase V0a1-dependent degradation in Alzheimer disease. Williamson WR, et al. Commun Integr Biol, 2010 Nov. PMID 21331254, Free PMC Article
  3. miR-1 sustains muscle physiology by controlling V-ATPase complex assembly. Gutiérrez-Pérez P, et al. Sci Adv, 2021 Oct 15. PMID 34652942, Free PMC Article
  4. Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration. Dubos A, et al. Hum Mol Genet, 2015 Dec 1. PMID 26376863, Free PMC Article
  5. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. Coen K, et al. J Cell Biol, 2012 Jul 9. PMID 22753898, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Ca(2+)-CaM regulation of V100 may control SNARE complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
    Title: Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.
  2. Neuron-specific, v100-dependent membrane sorting and degradation mechanism is required for brain wiring in Drosophila.
    Title: Guidance receptor degradation is required for neuronal connectivity in the Drosophila nervous system.
  3. V100-1 directs vesicle fusion independently of acidification. V100-1 is required for the acidification of a subset of neuronal lysosomes and autophagosomes but not synaptic vesicles and early endosomes.
    Title: A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATPase activity, rotational mechanism ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in endosomal lumen acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in terminal branching, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
vacuolar H[+] ATPase 100kD subunit 1
Names
CG1709-PA
CG1709-PB
CG1709-PC
CG1709-PD
CG1709-PE
CG1709-PF
CG1709-PG
CG1709-PI
CG1709-PJ
CG1709-PK
V0-ATPase a1
Vha100-1-PA
Vha100-1-PB
Vha100-1-PC
Vha100-1-PD
Vha100-1-PE
Vha100-1-PF
Vha100-1-PG
Vha100-1-PI
Vha100-1-PJ
Vha100-1-PK
neuron-specific V[[0]] subunit a1
vacuolar ATPase V0, subunit a1
vacuolar H[+] ATPase subunit 100-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29131193..29137980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170393.3 → NP_733272.1  vacuolar H[+] ATPase 100kD subunit 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733272.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML5
    Related
    FBpp0084745
    Conserved Domains (2) summary
    COG1269
    Location:27 → 820
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 820
    V_ATPase_I; V-type ATPase 116kDa subunit family

  2. NM_170395.3 → NP_733274.1  vacuolar H[+] ATPase 100kD subunit 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733274.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML2, Q8IML3
    Related
    FBpp0084744
    Conserved Domains (2) summary
    COG1269
    Location:27 → 823
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 823
    V_ATPase_I; V-type ATPase 116kDa subunit family

  3. NM_170391.3 → NP_733270.1  vacuolar H[+] ATPase 100kD subunit 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q9XZ10
    Related
    FBpp0084743
    Conserved Domains (2) summary
    COG1269
    Location:27 → 842
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 842
    V_ATPase_I; V-type ATPase 116kDa subunit family

  4. NM_001170298.2 → NP_001163769.1  vacuolar H[+] ATPase 100kD subunit 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163769.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLA3, Q86M57
    Conserved Domains (2) summary
    COG1269
    Location:27 → 839
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 839
    V_ATPase_I; V-type ATPase 116kDa subunit family

  5. NM_170394.3 → NP_733273.1  vacuolar H[+] ATPase 100kD subunit 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733273.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML4
    Related
    FBpp0084746
    Conserved Domains (2) summary
    COG1269
    Location:27 → 837
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 837
    V_ATPase_I; V-type ATPase 116kDa subunit family

  6. NM_170397.3 → NP_733276.3  vacuolar H[+] ATPase 100kD subunit 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733276.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML2, Q8IML3
    Conserved Domains (2) summary
    COG1269
    Location:27 → 823
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 823
    V_ATPase_I; V-type ATPase 116kDa subunit family

  7. NM_143415.3 → NP_651672.1  vacuolar H[+] ATPase 100kD subunit 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651672.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q9XZ10
    Related
    FBpp0084750
    Conserved Domains (2) summary
    COG1269
    Location:27 → 842
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 842
    V_ATPase_I; V-type ATPase 116kDa subunit family

  8. NM_170392.2 → NP_733271.1  vacuolar H[+] ATPase 100kD subunit 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML5
    Related
    FBpp0084748
    Conserved Domains (2) summary
    COG1269
    Location:27 → 820
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 820
    V_ATPase_I; V-type ATPase 116kDa subunit family

  9. NM_170396.2 → NP_733275.1  vacuolar H[+] ATPase 100kD subunit 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733275.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86M57, Q8IML2, Q8IML3
    Related
    FBpp0084749
    Conserved Domains (2) summary
    COG1269
    Location:27 → 823
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 823
    V_ATPase_I; V-type ATPase 116kDa subunit family

  10. NM_001170297.1 → NP_001163768.1  vacuolar H[+] ATPase 100kD subunit 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLA3, Q86M57
    Conserved Domains (2) summary
    COG1269
    Location:27 → 839
    NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
    pfam01496
    Location:28 → 839
    V_ATPase_I; V-type ATPase 116kDa subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NLA3 Q6NLA3
Q86M57 Q86M57
Q86P41 Q86P41
Q8IML3 Q8IML3
Q8IML4 Q8IML4
Q8IML5 Q8IML5
Q9XZ10 Q9XZ10

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