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jus julius seizure [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43453, updated on 4-Jan-2025

Summary

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Official Symbol
jusprovided by FlyBase
Official Full Name
julius seizureprovided by FlyBase
Primary source
FLYBASE:FBgn0039647
Locus tag
Dmel_CG14509
See related
AllianceGenome:FB:FBgn0039647
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14509; CG14510; Dmel\CG14509; Jus; sda
Summary
Involved in mechanosensory behavior and regulation of membrane potential. Is expressed in several structures, including adult cervical connective; adult head; ganglia; larval nervous system; and synaptic neuropil domain. Used to study epilepsy. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See jus in Genome Data Viewer
Location:
98F13-99A1; 3-97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29171191..29194994, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24996913..25020716, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regulatory particle non-ATPase 2 Neighboring gene red dog mine Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Metazoan SpoT homolog-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. Marley R, et al. J Neurophysiol, 2011 Jul. PMID 21451059, Free PMC Article
  2. Extending julius seizure, a bang-sensitive gene, as a model for studying epileptogenesis: Cold shock, and a new insertional mutation. Dean D, et al. Fly (Austin), 2018 Jan 2. PMID 29125376, Free PMC Article
  3. Muscle degeneration in aging Drosophila flies: the role of mechanical stress. Chechenova M, et al. Skelet Muscle, 2024 Aug 20. PMID 39164781, Free PMC Article
  4. Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. Kuebler D, et al. Brain Res, 2002 Dec 20. PMID 12468028
  5. Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. Reynolds ER, et al. J Neurobiol, 2004 Mar. PMID 14978727

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. julius seizure (jus), formerly CG14509, which encodes a novel transmembrane domain protein, is responsible for seizure sensitivity.
    Title: julius seizure, a Drosophila Mutant, Defines a Neuronal Population Underlying Epileptogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mechanical stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
julius seizure
Names
CG14509-PB
CG14509-PC
CG14509-PD
CG14509-PE
jus-PB
jus-PC
jus-PD
jus-PE
slamdance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29171191..29194994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276130.1 → NP_001263059.1  julius seizure, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHA7
    Conserved Domains (1) summary
    pfam01683
    Location:231 → 272
    EB; EB module

  2. NM_001276131.1 → NP_001263060.1  julius seizure, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHT8
    Conserved Domains (1) summary
    pfam01683
    Location:231 → 272
    EB; EB module

  3. NM_001104492.2 → NP_001097962.1  julius seizure, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097962.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQS2
    Conserved Domains (1) summary
    pfam01683
    Location:231 → 272
    EB; EB module

  4. NM_001104493.2 → NP_001097963.1  julius seizure, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097963.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q32KC6
    Conserved Domains (1) summary
    pfam01683
    Location:231 → 272
    EB; EB module
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHA7 A0A0B4KHA7
A0A0B4KHT8 A0A0B4KHT8
Q32KC6 Q32KC6
Q8MQS2 Q8MQS2

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