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Slc22a28 solute carrier family 22, member 28 [ Mus musculus (house mouse) ]

Gene ID: 434674, updated on 4-Jan-2025

Summary

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Official Symbol
Slc22a28provided by MGI
Official Full Name
solute carrier family 22, member 28provided by MGI
Primary source
MGI:MGI:3645714
See related
Ensembl:ENSMUSG00000063590 AllianceGenome:MGI:3645714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5631; EG434674
Summary
Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward liver adult (RPKM 24.4) See more
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Genomic context

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See Slc22a28 in Genome Data Viewer
Location:
19 A; 19 5.39 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8039323..8109346, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8061958..8131982, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22, member 27 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene calpastatin pseudogene Neighboring gene STARR-seq mESC enhancer starr_45475 Neighboring gene solute carrier family 22. member 29 Neighboring gene predicted gene, 41804 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables short-chain fatty acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 22, member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013820.3 → NP_001013842.2  solute carrier family 22, member 28

    See identical proteins and their annotated locations for NP_001013842.2

    Status: VALIDATED

    Source sequence(s)
    AK052719, BC139174
    Consensus CDS
    CCDS29534.1
    UniProtKB/TrEMBL
    B2RT89, Q8BWE8
    Related
    ENSMUSP00000067114.5, ENSMUST00000065651.5
    Conserved Domains (2) summary
    cd06174
    Location:151 → 516
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8039323..8109346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527179.3 → XP_006527242.1  solute carrier family 22, member 28 isoform X1

    UniProtKB/TrEMBL
    Q8BWE8
    Conserved Domains (1) summary
    cd17374
    Location:88 → 495
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

  2. XM_011247277.2 → XP_011245579.1  solute carrier family 22, member 28 isoform X2

    UniProtKB/TrEMBL
    Q8BWE8
    Conserved Domains (1) summary
    cd17374
    Location:73 → 480
    MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

  3. XM_011247278.2 → XP_011245580.1  solute carrier family 22, member 28 isoform X3

    UniProtKB/TrEMBL
    Q8BWE8
    Conserved Domains (1) summary
    cl28910
    Location:109 → 408
    MFS; Major Facilitator Superfamily

  4. XM_030250984.1 → XP_030106844.1  solute carrier family 22, member 28 isoform X6

    UniProtKB/TrEMBL
    Q810T7
    Conserved Domains (1) summary
    cl28910
    Location:109 → 428
    MFS; Major Facilitator Superfamily

  5. XM_011247279.1 → XP_011245581.1  solute carrier family 22, member 28 isoform X4

    Conserved Domains (1) summary
    cl28910
    Location:109 → 279
    MFS; Major Facilitator Superfamily

  6. XM_006527180.2 → XP_006527243.1  solute carrier family 22, member 28 isoform X5

    Conserved Domains (1) summary
    cl28910
    Location:109 → 275
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version

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