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Trc8 TRC8 ring finger protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43476, updated on 9-Dec-2024

Summary

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Official Symbol
Trc8provided by FlyBase
Official Full Name
TRC8 ring finger proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039668
Locus tag
Dmel_CG2304
See related
AllianceGenome:FB:FBgn0039668
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2304; Dmel\CG2304; Dtrc8; DTrc8; trc8; TRC8
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of growth and ventral midline development. Located in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Trc8 in Genome Data Viewer
Location:
99B1-99B1; 3-99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29499025..29503797, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25324747..25329519, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene diedel Neighboring gene F-box involved in polyQ pathogenesis Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit-like Neighboring gene long non-coding RNA:CR43613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. msh specifies dorsal cell fate in the Drosophila wing. Milán M, et al. Development, 2001 Sep. PMID 11546743
  2. Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1/CSN5. Gemmill RM, et al. Oncogene, 2005 May 12. PMID 15735686
  3. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Gemmill RM, et al. Oncogene, 2002 May 16. PMID 12032852
  4. An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation. Kim M, et al. PLoS Genet, 2018 Feb. PMID 29420631, Free PMC Article
  5. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventral midline development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TRC8 ring finger protein
Names
CG2304-PA
CG2304-PB
CG2304-PD
CG2304-PE
TRC8 ortholog
Trc8-PA
Trc8-PB
Trc8-PD
Trc8-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29499025..29503797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276141.1 → NP_001263070.1  TRC8 ring finger protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V3L3
    Conserved Domains (3) summary
    pfam12678
    Location:613 → 654
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:614 → 654
    zf-RING_2; Ring finger domain
    pfam13705
    Location:122 → 585
    TRC8_N; TRC8 N-terminal domain

  2. NM_170414.2 → NP_733293.1  TRC8 ring finger protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V3L3
    Related
    FBpp0084798
    Conserved Domains (3) summary
    pfam12678
    Location:613 → 654
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:614 → 654
    zf-RING_2; Ring finger domain
    pfam13705
    Location:122 → 585
    TRC8_N; TRC8 N-terminal domain

  3. NM_206580.2 → NP_996303.1  TRC8 ring finger protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996303.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KRW0, Q7KRW1, Q8IHG9, Q8MQX1, Q8T0E3, Q8WRY2, Q9VAK6
    Conserved Domains (3) summary
    pfam12678
    Location:618 → 659
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:619 → 659
    zf-RING_2; Ring finger domain
    pfam13705
    Location:122 → 590
    TRC8_N; TRC8 N-terminal domain

  4. NM_170413.3 → NP_733292.1  TRC8 ring finger protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733292.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V3L3
    Related
    FBpp0084797
    Conserved Domains (3) summary
    pfam12678
    Location:613 → 654
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:614 → 654
    zf-RING_2; Ring finger domain
    pfam13705
    Location:122 → 585
    TRC8_N; TRC8 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V3L3 A4V3L3
Q7KRW1.1 Q7KRW1

Gene LinkOut

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