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Kul Kuzbanian-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43501, updated on 4-Jan-2025

Summary

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Official Symbol
Kulprovided by FlyBase
Official Full Name
Kuzbanian-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0039688
Locus tag
Dmel_CG1964
See related
AllianceGenome:FB:FBgn0039688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADAM10; CG1964; CT3146; Dmel\CG1964; kul
Summary
Enables metalloendopeptidase activity. Involved in Notch signaling pathway and membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Kul in Genome Data Viewer
Location:
99B9-99B9; 3-99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29725830..29735360)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25551552..25561082)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pterin-4a-carbinolamine dehydratase Neighboring gene N(alpha)-acetyltransferase 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Complex I intermediate-associated protein, 30 kDa Neighboring gene Glucosamine-phosphate N-acetyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Non-Cell-Autonomous Function of the GPI-Anchored Protein Undicht during Septate Junction Assembly. Petri J, et al. Cell Rep, 2019 Feb 5. PMID 30726744
  2. kuzbanian-mediated cleavage of Drosophila Notch. Lieber T, et al. Genes Dev, 2002 Jan 15. PMID 11799064, Free PMC Article
  3. Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease. Reinhardt S, et al. Cell Mol Life Sci, 2019 Mar. PMID 30599067, Free PMC Article
  4. E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans. Revici R, et al. Biomolecules, 2022 Jan 27. PMID 35204725, Free PMC Article
  5. IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells. Fic W, et al. Development, 2019 Jan 18. PMID 30635283, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Kuzbanian-like
Names
ADAM10
CG1964-PA
CG1964-PB
CG1964-PC
Kul-PA
Kul-PB
Kul-PC
NP_001287589.1
NP_001287590.1
NP_651716.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29725830..29735360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300660.1 → NP_001287589.1  Kuzbanian-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6QU66, Q9VAI2
    Conserved Domains (4) summary
    cd04270
    Location:479 → 713
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:720 → 803
    Disintegrin; Disintegrin
    pfam01562
    Location:72 → 174
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:502 → 696
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  2. NM_001300661.1 → NP_001287590.1  Kuzbanian-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287590.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHU2
    Conserved Domains (4) summary
    cd04270
    Location:479 → 713
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:720 → 803
    Disintegrin; Disintegrin
    pfam01562
    Location:72 → 174
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:502 → 696
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  3. NM_143459.3 → NP_651716.1  Kuzbanian-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6QU66, Q9VAI2
    Related
    FBpp0084826
    Conserved Domains (4) summary
    cd04270
    Location:479 → 713
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:720 → 803
    Disintegrin; Disintegrin
    pfam01562
    Location:72 → 174
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:502 → 696
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHU2 A0A0B4LHU2
Q9VAI2 Q9VAI2

Gene LinkOut

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