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Wdr24 WD repeat domain 24 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43505, updated on 4-Jan-2025

Summary

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Official Symbol
Wdr24provided by FlyBase
Official Full Name
WD repeat domain 24provided by FlyBase
Primary source
FLYBASE:FBgn0027518
Locus tag
Dmel_CG7609
See related
AllianceGenome:FB:FBgn0027518
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21720; CG7609; Dmel\CG7609; FBtr0085543; GATOR2; Sea2; SEA2; wdr24; WDR24
Summary
Involved in several processes, including cellular response to amino acid starvation; lysosomal lumen acidification; and positive regulation of TORC1 signaling. Located in autolysosome. Part of Seh1-associated complex. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Wdr24 in Genome Data Viewer
Location:
99B9-99B10; 3-99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29741972..29745092, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25567694..25570814, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Complex I intermediate-associated protein, 30 kDa Neighboring gene Glucosamine-phosphate N-acetyltransferase Neighboring gene antisense RNA:CR46109 Neighboring gene Integrator 11 Neighboring gene ATP synthase, gamma subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction. Yang S, et al. Dev Cell, 2020 Nov 9. PMID 32898476, Free PMC Article
  2. Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Gu X, et al. Nature, 2022 Aug. PMID 35859173, Free PMC Article
  3. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Kim JS, et al. Sci Rep, 2015 Mar 30. PMID 25819761, Free PMC Article
  4. Wdr59 promotes or inhibits TORC1 activity depending on cellular context. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 3. PMID 36577058, Free PMC Article
  5. An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Liu GY, et al. Nat Commun, 2024 Mar 21. PMID 38514639, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosomal lumen acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GATOR2 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of Seh1-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Seh1-associated complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in autolysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat domain 24
Names
CG7609-PB
CG7609-PC
Wdr24-PB
Wdr24-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29741972..29745092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143463.5 → NP_651720.3  WD repeat domain 24, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651720.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XZ25
    Related
    FBpp0084909
    Conserved Domains (4) summary
    COG2319
    Location:22 → 312
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13 → 311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:70 → 109
    7WD40; WD40 repeat [structural motif]
    cl24077
    Location:719 → 776
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type

  2. NM_170424.2 → NP_733303.2  WD repeat domain 24, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733303.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BR7
    Conserved Domains (4) summary
    COG2319
    Location:22 → 312
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13 → 311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:70 → 109
    7WD40; WD40 repeat [structural motif]
    cl24077
    Location:720 → 777
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BR7 Q86BR7
Q9XZ25.1 Q9XZ25

Gene LinkOut

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