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Prtl99C Protamine-like 99C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43526, updated on 9-Dec-2024

Summary

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Official Symbol
Prtl99Cprovided by FlyBase
Official Full Name
Protamine-like 99Cprovided by FlyBase
Primary source
FLYBASE:FBgn0039707
Locus tag
Dmel_CG15510
See related
AllianceGenome:FB:FBgn0039707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT14346; CG15510; Dmel\CG15510
Summary
Involved in sperm DNA condensation. Located in nucleus. Is expressed in male germline cell; seminal vesicle; and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Prtl99C in Genome Data Viewer
Location:
99C2-99C3; 3-99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29835950..29837447)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25661672..25663169)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene neyo Neighboring gene Autophagy-related 16 Neighboring gene uncharacterized protein Neighboring gene Cadherin 99C Neighboring gene dim gamma-tubulin 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. Hundertmark T, et al. PLoS One, 2018. PMID 30192860, Free PMC Article
  2. Prtl99C Acts Together with Protamines and Safeguards Male Fertility in Drosophila. Eren-Ghiani Z, et al. Cell Rep, 2015 Dec 22. PMID 26673329
  3. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
  4. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447
  5. Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. Rathke C, et al. J Cell Sci, 2007 May 1. PMID 17452629

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in sperm DNA condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protamine-like 99C
Names
CG15510-PB
CG15510-PC
CG15510-PD
Prtl99C-PB
Prtl99C-PC
Prtl99C-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29835950..29837447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143478.3 → NP_651735.3  Protamine-like 99C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651735.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJ16, F2FB58, Q8MZC5, Q9VAF7
    Conserved Domains (1) summary
    pfam06382
    Location:1 → 125
    DUF1074; Protein of unknown function (DUF1074)

  2. NM_001300665.1 → NP_001287594.1  Protamine-like 99C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJ16, F2FB58, Q8MZC5, Q9VAF7
    Conserved Domains (1) summary
    pfam06382
    Location:1 → 125
    DUF1074; Protein of unknown function (DUF1074)

  3. NM_001170300.2 → NP_001163771.1  Protamine-like 99C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAF7
    Conserved Domains (1) summary
    pfam06382
    Location:1 → 117
    DUF1074; Protein of unknown function (DUF1074)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAF7.3 Q9VAF7

Gene LinkOut

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