MPO myeloperoxidase [Homo sapiens (human)] - Gene

Summary

Official Symbol: MPOprovided by HGNC
Official Full Name: myeloperoxidaseprovided by HGNC
Primary source: HGNC:HGNC:7218
See related: Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Expression: Restricted expression toward bone marrow (RPKM 1596.3) See more
Orthologs: mouse all
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Genomic context

Location:: 17q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (58269855..58280935, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (59137736..59148814, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (56347216..56358296, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].
Title: [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].
The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.
Title: The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.
Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.
Title: Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.
Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.
Title: Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.
Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
Title: Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Title: Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.
Title: Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.
Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
Title: Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation.
Title: Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation.
NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
Title: NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (491)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Alzheimer disease type 1 MedGen: C1863052 OMIM: 104300 GeneReviews: Alzheimer Disease Overview	Compare labs
Myeloperoxidase deficiency MedGen: C0398595 OMIM: 254600 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of myeloperoxidase (MPO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates myeloperoxidase in HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45018 (e-PCR)
- UniSTS:2825

D17S1716 (e-PCR)
- UniSTS:18188

GDB:178575 (e-PCR)
- UniSTS:155027

GDB:196134 (e-PCR)
- UniSTS:155816

STS-M19507 (e-PCR)
- UniSTS:18371

D17S1975 (e-PCR)
- UniSTS:33742

GDB:180938 (e-PCR)
- UniSTS:155132

GDB:191092 (e-PCR)
- UniSTS:155644

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	TAS Traceable Author Statement more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to fungus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hypochlorous acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in respiratory burst involved in defense response	IEA Inferred from Electronic Annotation more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in response to gold nanoparticle	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	TAS Traceable Author Statement more info	PubMed
involved_in response to yeast	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in azurophil granule	IDA Inferred from Direct Assay more info	PubMed
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lysosome	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	HDA more info	PubMed
located_in phagocytic vesicle lumen	TAS Traceable Author Statement more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myeloperoxidase

NP_000241.1

EC 1.11.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.