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Zip99C Zinc/iron regulated transporter-related protein 99C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43533, updated on 9-Dec-2024

Summary

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Official Symbol
Zip99Cprovided by FlyBase
Official Full Name
Zinc/iron regulated transporter-related protein 99Cprovided by FlyBase
Primary source
FLYBASE:FBgn0039714
Locus tag
Dmel_CG7816
See related
AllianceGenome:FB:FBgn0039714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg7816; CG7816; Dmel\CG7816; dZip13; dZIP13; dZip99C; Zip13; ZIP13; ZIP99C
Summary
Enables iron ion binding activity and iron ion transmembrane transporter activity. Involved in detoxification of zinc ion; iron ion transport; and multicellular organismal-level iron ion homeostasis. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval crystal cell; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 3. Orthologous to human SLC39A13 (solute carrier family 39 member 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Zip99C in Genome Data Viewer
Location:
99C4-99C5; 3-99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29863701..29868895, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25689423..25694617, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster. Liu ZH, et al. Chemosphere, 2020 Mar. PMID 31995880
  2. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Xiao G, et al. Elife, 2014 Jul 8. PMID 25006035, Free PMC Article
  3. Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization. Xu J, et al. Biochim Biophys Acta Mol Cell Res, 2019 Sep. PMID 31229649
  4. Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Xiao G, et al. Cell Rep, 2019 Jan 15. PMID 30650364
  5. A distinctive sequence motif in the fourth transmembrane domain confers ZIP13 iron function in Drosophila melanogaster. Zhao M, et al. Biochim Biophys Acta Mol Cell Res, 2020 Feb. PMID 31733261

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.
    Title: The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in detoxification of zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc/iron regulated transporter-related protein 99C
Names
CG7816-PA
CG7816-PC
CG7816-PD
CG7816-PE
CG7816-PF
CG7816-PG
CG7816-PH
CG7816-PI
CG7816-PJ
Zip99C-PA
Zip99C-PC
Zip99C-PD
Zip99C-PE
Zip99C-PF
Zip99C-PG
Zip99C-PH
Zip99C-PI
Zip99C-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29863701..29868895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202386.2 → NP_001189315.1  Zinc/iron regulated transporter-related protein 99C, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  2. NM_001202385.2 → NP_001189314.1  Zinc/iron regulated transporter-related protein 99C, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189314.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  3. NM_170444.3 → NP_733323.1  Zinc/iron regulated transporter-related protein 99C, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733323.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088864
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  4. NM_170445.2 → NP_733324.1  Zinc/iron regulated transporter-related protein 99C, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733324.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088863
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  5. NM_170440.2 → NP_733319.1  Zinc/iron regulated transporter-related protein 99C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733319.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088862
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  6. NM_170442.2 → NP_733321.1  Zinc/iron regulated transporter-related protein 99C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088861
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  7. NM_001202384.1 → NP_001189313.1  Zinc/iron regulated transporter-related protein 99C, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189313.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  8. NM_170443.3 → NP_733322.1  Zinc/iron regulated transporter-related protein 99C, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733322.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088860
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter

  9. NM_170441.2 → NP_733320.1  Zinc/iron regulated transporter-related protein 99C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733320.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YH2, Q9VAF0
    UniProtKB/TrEMBL
    A4V3L8
    Related
    FBpp0088859
    Conserved Domains (1) summary
    pfam02535
    Location:34 → 350
    Zip; ZIP Zinc transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V3L8 A4V3L8
Q95T93 Q95T93
Q9VAF0.1 Q9VAF0

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