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Jasper JIL-1 anchoring and stabilizing protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43576, updated on 2-Nov-2024

Summary

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Official Symbol
Jasperprovided by FlyBase
Official Full Name
JIL-1 anchoring and stabilizing proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039743
Locus tag
Dmel_CG7946
See related
AllianceGenome:FB:FBgn0039743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7946; Dmel\CG7946; dP75; JASPer
Summary
Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to several human genes including HDGFL2 (HDGF like 2) and PSIP1 (PC4 and SRSF1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Jasper in Genome Data Viewer
Location:
99D3-99D3; 3-100 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30052514..30054697)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25878236..25880419)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44046 Neighboring gene uncharacterized protein Neighboring gene spindle A Neighboring gene Ribonuclease P/MRP subunit p14 b Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p14 a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading. Dou K, et al. J Genet Genomics, 2020 Apr 20. PMID 32499180, Free PMC Article
  2. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Albig C, et al. Nat Commun, 2019 Nov 25. PMID 31767855, Free PMC Article
  3. The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. Johannessen JA, et al. iScience, 2023 Oct 20. PMID 37720104, Free PMC Article
  4. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, et al. Nat Struct Mol Biol, 2013 Feb. PMID 23295261, Free PMC Article
  5. Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases. Kline RA, et al. PLoS Genet, 2017 Mar. PMID 28362802, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading.
    Title: Drosophila P75 safeguards oogenesis by preventing H3K9me2 spreading.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
JIL-1 anchoring and stabilizing protein
Names
CG7946-PA
CG7946-PB
Jasper-PA
Jasper-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30052514..30054697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143511.3 → NP_651768.1  JIL-1 anchoring and stabilizing protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAA9
    Related
    FBpp0084927
    Conserved Domains (2) summary
    cd05834
    Location:8 → 88
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:320 → 440
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

  2. NM_001276170.1 → NP_001263099.1  JIL-1 anchoring and stabilizing protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263099.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VAA9
    Conserved Domains (2) summary
    cd05834
    Location:8 → 88
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:320 → 440
    LEDGF; Lens epithelium-derived growth factor (LEDGF)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAA9 Q9VAA9

Gene LinkOut

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