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Tpi - Triose phosphate isomerase

Enables protein homodimerization activity and triose-phosphate isomerase activity. Involved in several processes, including canonical glycolysis; determination of adult lifespan; and glucose homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; larval muscle system; muscle cell; and spermatozoon. Used to study neurodegenerative disease and triosephosphate isomerase deficiency. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa