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Tmprss11c transmembrane protease, serine 11c [ Mus musculus (house mouse) ]

Gene ID: 435845, updated on 4-Jan-2025

Summary

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Official Symbol
Tmprss11cprovided by MGI
Official Full Name
transmembrane protease, serine 11cprovided by MGI
Primary source
MGI:MGI:3521861
See related
Ensembl:ENSMUSG00000061184 AllianceGenome:MGI:3521861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmprss13
Summary
Enables serine-type endopeptidase activity. Involved in self proteolysis. Located in dendrite; perikaryon; and plasma membrane. Orthologous to human TMPRSS11CP (transmembrane serine protease 11C, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Tmprss11c in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86376600..86437167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86231481..86289308, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene STARR-seq mESC enhancer starr_13545 Neighboring gene predicted gene, 25473 Neighboring gene transmembrane protease, serine 11d Neighboring gene STARR-seq mESC enhancer starr_13546 Neighboring gene STARR-seq mESC enhancer starr_13547 Neighboring gene STARR-seq mESC enhancer starr_13548 Neighboring gene predicted gene, 35367 Neighboring gene STARR-seq mESC enhancer starr_13549 Neighboring gene transmembrane protease, serine 11a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2 in vitro. Stallmach R, et al. Biochem J, 2008 May 15. PMID 18215125
  2. Iterative, multiplexed CRISPR-mediated gene editing for functional analysis of complex protease gene clusters. Callies LK, et al. J Biol Chem, 2019 Nov 1. PMID 31501243, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurobin is an authentic transmembrane serine protease with trypsin-like activity and is able to process FGF-2 in vitro.
    Title: Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2 in vitro.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in self proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protease serine 11C
Names
neurobin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030297.3 → NP_001025468.1  transmembrane protease serine 11C

    See identical proteins and their annotated locations for NP_001025468.1

    Status: VALIDATED

    Source sequence(s)
    AC100746
    Consensus CDS
    CCDS19380.1
    UniProtKB/Swiss-Prot
    Q1JRP2
    UniProtKB/TrEMBL
    A0A0G2JET7
    Related
    ENSMUSP00000062915.6, ENSMUST00000059424.10
    Conserved Domains (3) summary
    smart00020
    Location:199 → 425
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:200 → 428
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:62 → 157
    SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    86376600..86437167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1JRP2.1 GenPept UniProtKB/Swiss-Prot:Q1JRP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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