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CG9733 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43601, updated on 9-Dec-2024

Summary

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Official Symbol
CG9733provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039759
Locus tag
Dmel_CG9733
See related
AllianceGenome:FB:FBgn0039759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SP10; cSP10; Dmel\CG9733; proAE; proPO-AE; SP10
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG9733 in Genome Data Viewer
Location:
99E3-99E3; 3-100 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30243978..30246703, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26069700..26072425, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Leucine-TAG 1-1 Neighboring gene transfer RNA:Leucine-TAG 1-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and regulation of Spätzle-processing enzyme in Drosophila. Mulinari S, et al. FEBS Lett, 2006 Oct 2. PMID 16996061
  2. Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Marshall KE, et al. Proc Biol Sci, 2010 Mar 22. PMID 19939842, Free PMC Article
  3. Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster. Winterhalter WE, et al. Proc Biol Sci, 2009 Mar 22. PMID 19129115, Free PMC Article
  4. A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity. Jang IH, et al. Dev Cell, 2006 Jan. PMID 16399077
  5. Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging. Rai M, et al. Cell Metab, 2021 Jun 1. PMID 33773104, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9733-PA
CG9733-PB
POAE-like serine protease
pro-phenoloxidase AE
NP_001287606.1
NP_651784.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30243978..30246703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300677.1 → NP_001287606.1  uncharacterized protein Dmel_CG9733, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHW2, Q8SZK2
    Conserved Domains (3) summary
    smart00020
    Location:160 → 411
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:161 → 414
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam12032
    Location:24 → 77
    CLIP; Regulatory CLIP domain of proteinases

  2. NM_143527.3 → NP_651784.2  uncharacterized protein Dmel_CG9733, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651784.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZK2, Q9VA87
    Related
    FBpp0085000
    Conserved Domains (3) summary
    smart00020
    Location:161 → 412
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:162 → 415
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam12032
    Location:25 → 78
    CLIP; Regulatory CLIP domain of proteinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHW2 A0A0B4LHW2
Q8SZK2 Q8SZK2
Q9VA87 Q9VA87

Gene LinkOut

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