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PH4alphaNE1 prolyl-4-hydroxylase-alpha NE1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43625, updated on 4-Jan-2025

Summary

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Official Symbol
PH4alphaNE1provided by FlyBase
Official Full Name
prolyl-4-hydroxylase-alpha NE1provided by FlyBase
Primary source
FLYBASE:FBgn0039780
Locus tag
Dmel_CG9728
See related
AllianceGenome:FB:FBgn0039780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9728; Dmel\CG9728
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See PH4alphaNE1 in Genome Data Viewer
Location:
99F6-99F6; 3-100 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30496751..30500326, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26322473..26326048, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene prolyl-4-hydroxylase-alpha MP Neighboring gene uncharacterized protein Neighboring gene prolyl-4-hydroxylase-alpha SG1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
  2. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497
  3. Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Pegoraro M, et al. Front Neurol, 2015. PMID 26097463, Free PMC Article
  4. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl-4-hydroxylase-alpha NE1
Names
CG9728-PA
PH4alphaNE1-PA
NP_733374.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30496751..30500326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170495.2 → NP_733374.1  prolyl-4-hydroxylase-alpha NE1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C3KGL2, Q9VA64
    Related
    FBpp0085050
    Conserved Domains (2) summary
    smart00702
    Location:341 → 511
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:26 → 155
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T0N6 Q8T0N6
Q8T5S6 Q8T5S6
Q9VA64 Q9VA64

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