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metl-2 tRNA N(3)-methylcytidine methyltransferase [ Caenorhabditis elegans ]

Gene ID: 4363033, updated on 9-Dec-2024

Summary

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Official Symbol
metl-2
Official Full Name
tRNA N(3)-methylcytidine methyltransferase
Primary source
WormBase:WBGene00044720
Locus tag
CELE_Y53F4B.42
See related
AllianceGenome:WB:WBGene00044720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in RNA methylation. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See metl-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (14969900..14971657)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (cytidine-3-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA N(3)-methylcytidine methyltransferase
NP_001040827.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    14969900..14971657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047362.5 → NP_001040827.1  tRNA N(3)-methylcytidine methyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MDF2
    Conserved Domains (3) summary
    COG0500
    Location:70 → 309
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:122 → 226
    Methyltransf_12; Methyltransferase domain
    cl17173
    Location:206 → 278
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
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