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PH4alphaPV prolyl-4-hydroxylase-alpha PV [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43640, updated on 4-Jan-2025

Summary

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Official Symbol
PH4alphaPVprovided by FlyBase
Official Full Name
prolyl-4-hydroxylase-alpha PVprovided by FlyBase
Primary source
FLYBASE:FBgn0051015
Locus tag
Dmel_CG31015
See related
AllianceGenome:FB:FBgn0051015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31015; CG9713; Dmel\CG31015
Summary
Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be active in endoplasmic reticulum. Is expressed in embryonic proventriculus and proventriculus primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See PH4alphaPV in Genome Data Viewer
Location:
100A1-100A1; 3-101 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30646106..30648551, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26471828..26474273, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46236 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
  2. The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Landis GN, et al. Aging (Albany NY), 2015 Jan. PMID 25614682, Free PMC Article
  3. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article
  4. Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Pegoraro M, et al. Front Neurol, 2015. PMID 26097463, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen-proline 4-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl-4-hydroxylase-alpha PV
Names
CG31015-PA
PH4alphaPV-PA
NP_733395.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30646106..30648551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170516.1 → NP_733395.1  prolyl-4-hydroxylase-alpha PV [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T5S8
    Related
    FBpp0085032, FBtr0085670
    Conserved Domains (4) summary
    smart00702
    Location:339 → 510
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    sd00006
    Location:179 → 213
    TPR; TPR repeat [structural motif]
    pfam08336
    Location:35 → 164
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    pfam13414
    Location:179 → 250
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQN0 Q8MQN0
Q8T5S8 Q8T5S8

Gene LinkOut

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