U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) [ Danio rerio (zebrafish) ]

Gene ID: 436607, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
kpna2provided by ZNC
Official Full Name
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-22
See related
Ensembl:ENSDARG00000038066 AllianceGenome:ZFIN:ZDB-GENE-040718-22
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zeh0389; zeh0389r; zgc:86945; hm:zeh0389; zgc:113902; hm:zeh0389r
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kpna2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25369980..25377017, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25239432..25246469, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene bromodomain PHD finger transcription factor Neighboring gene transfer RNA serine (anticodon AGA)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. Figueiredo MA, et al. J Mol Endocrinol, 2016 Jan. PMID 26553237
  2. Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay. Chen GD, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16616005
  3. Shedding new light on early sex determination in zebrafish. King AC, et al. Arch Toxicol, 2020 Dec. PMID 32975586, Free PMC Article
  4. Identification of zygotic genes expressed at the midblastula transition in zebrafish. O'Boyle S, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17490614
  5. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC113902

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
importin subunit alpha-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002335.1 → NP_001002335.1  importin subunit alpha-1

    See identical proteins and their annotated locations for NP_001002335.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075790
    UniProtKB/TrEMBL
    Q6DI01
    Related
    ENSDARP00000055489.4, ENSDART00000055490.7
    Conserved Domains (5) summary
    COG5064
    Location:9 → 525
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:110 → 235
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:9 → 95
    IBB; Importin beta binding domain
    pfam16186
    Location:455 → 505
    Arm_3; Atypical Arm repeat
    sd00043
    Location:112 → 144
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    25369980..25377017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.