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CG15547 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43661, updated on 9-Dec-2024

Summary

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Official Symbol
CG15547provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039809
Locus tag
Dmel_CG15547
See related
AllianceGenome:FB:FBgn0039809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG15547
Summary
Predicted to be involved in cilium movement and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Predicted to be active in cilium. Is expressed in spermatogonium and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG15547 in Genome Data Viewer
Location:
100A6-100A6; 3-101 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30881792..30883503, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26707514..26709225, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Saposin-related Neighboring gene Cytochrome P450 4c3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fat body-specific reduction of CTPS alleviates HFD-induced obesity. Liu J, et al. Elife, 2023 Sep 11. PMID 37695169, Free PMC Article
  2. Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease. Huichalaf CH, et al. Hum Mol Genet, 2019 Jun 15. PMID 30753434, Free PMC Article
  3. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
  4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
  5. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG15547-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30881792..30883503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143576.2 → NP_651833.1  uncharacterized protein Dmel_CG15547 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHE4, Q9VA28
    Related
    FBpp0085077
    Conserved Domains (2) summary
    smart00562
    Location:3 → 120
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cl00335
    Location:3 → 119
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IHE4 Q8IHE4
Q9VA28 Q9VA28

Gene LinkOut

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