5-HT7 5-hydroxytryptamine (serotonin) receptor 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT7provided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 7provided by FlyBase
Primary source: FLYBASE:FBgn0004573
Locus tag: Dmel_CG12073
See related: AllianceGenome:FB:FBgn0004573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT-7; 5-HT-dro; 5-HT-dro1; 5-HT2A; 5-HT7Dro; 5-HTdro1; 5-HT[7]Dro; 5-HT[[7Dro]]; 5-HT[[7]]; 5-HT[[7]]Dro; 5-HT[[7]]R; 5-HT[[dro1]]; 5HT-7; 5HT-dro; 5HT-dro1; 5HT-R1; 5HT7; 5htdror; 5HT[[7Dro]]; CG12073; Dm5-HT7; Dm5-HT[[7]]; Dm5HTdro1; Dmel\CG12073; DRO1; HT7
Summary: Enables G protein-coupled serotonin receptor activity. Involved in female mating behavior; male courtship behavior; and serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including adult ellipsoid body ring neurons; brain; ellipsoid body layer; synaptic neuropil domain; and ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30968236..31016875, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26793958..26842597, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

5-HT(7)Dro activity is essential for normal courtship and mating behaviors in the fly
Title: The serotonin 5-HT7Dro receptor is expressed in the brain of Drosophila, and is essential for normal courtship and mating.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled serotonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, orientation prior to leg tapping and wing vibration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, proboscis-mediated licking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior, veined wing vibration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: 5-HT7-PA; 5-HT7-PB; CG12073-PA; CG12073-PB; serotonin receptor; serotonin receptor 1; serotonin receptor 7

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