dco discs overgrown [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dcoprovided by FlyBase
Official Full Name: discs overgrownprovided by FlyBase
Primary source: FLYBASE:FBgn0002413
Locus tag: Dmel_CG2048
See related: AllianceGenome:FB:FBgn0002413
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0538/13; 0915/10; 1396/02; 1447/01; 1460/09; CG2048; CK1delta/epsilon; ck1epsilon; CK1epsilon; CKIepsilon; dbt; Dbt; DBT; DBT/CK1epsilon; dCKIepsilon; Dco; DCO; dco-1; Dco/CK1; DCO/CKIe; ddbt; Dmel\CG2048; l(3)dco; l(3)dco-1; l(3)discs overgrown; l(3)discs overgrown-1; l(3)j3B9; l(3)rK215; l(3)S053813; l(3)S144701
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including behavioral response to cocaine; regulation of protein metabolic process; and regulation of signal transduction. Located in cell body; cytosol; and nucleus. Colocalizes with plasma membrane. Is expressed in several structures, including brain; embryonic/larval midgut primordium; germline cell; mesoderm; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 2 and invasive ductal carcinoma. Orthologous to several human genes including TPTEP2-CSNK1E (TPTEP2-CSNK1E readthrough) and CSNK1E (casein kinase 1 epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100B1-100B2; 3-102 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31054085..31061210, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26879807..26886932, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DBT affects sleep in both circadian and non-circadian neurons.
Title: DBT affects sleep in both circadian and non-circadian neurons.
Loss of the Drosophila branched-chain alpha-ketoacid dehydrogenase complex results in neuronal dysfunction.
Title: Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction.
DAnkrd49 and Bdbt act via Casein kinase Iepsilon to regulate planar polarity in Drosophila.
Title: DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila.
The authors conclude that Casein Kinase Iepsilon phosphorylation acts as a switch, promoting Strabismus mobility and Dishevelled immobility, thus enhancing sorting of these proteins to opposite cell edges.
Title: Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.
Phosphorylation of PER residue S589 stabilizes and activates PER inhibitory function in the presence of TIM, but promotes PER degradation in its absence. The role of DBT in regulating PER activity, stabilization and degradation ensures that these events are chronologically and biochemically linked, and contributes to the timing of an essential delay that influences the period of the circadian clock.
Title: CK1/Doubletime activity delays transcription activation in the circadian clock.
DBT plays a dual role on PER in control of this core mechanism (i) by relieving the effects of PER on the transcriptional repression when it targets nuclear PER for degradation and (ii) by delaying PER's nuclear localization when targeting its degradation in the cytoplasm.
Title: The Circadian tau Mutation in Casein Kinase 1 Is Part of a Larger Domain That Can Be Mutated to Shorten Circadian Period.
results demonstrate that Bride of Doubletime (BDBT) interacts with doubletime(DBT)in a manner requiring the DBT nuclear localization signal for nuclear localization and that the interaction is required to produce a fully functional circadian complex
Title: A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function.
we show that spag knock-down or reduced Dbt activity in circadian cells leads to longer circadian periods and expression of activated initiator caspase only during the middle of the day.
Title: Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy.
Responses of the clock to light via the regulated translation of DBT.
Title: Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.
Data show that the HSP-90 cochaperone spaghetti protein (SPAG) antagonizes casein kinase I epsilon DBT autophosphorylation in S2 cells
Title: Drosophila DBT Autophosphorylation of Its C-Terminal Domain Antagonized by SPAG and Involved in UV-Induced Apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IPI Inferred from Physical Interaction more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ecdysteroid secretion	IMP Inferred from Mutant Phenotype more info
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: discs overgrown

Names: CG2048-PA; CG2048-PB; CG2048-PC; CG2048-PD; CG2048-PE; casein kinase 1; casein kinase I epsilon; casein kinase iepsilon; dco-PA; dco-PB; dco-PC; dco-PD; dco-PE; disc overgrown; double time; double-time; doubletime

NP_001263132.1

EC 2.7.11.1

NP_001356928.1

EC 2.7.11.1

NP_524602.1

EC 2.7.11.1

NP_733414.1

EC 2.7.11.1

NP_733415.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31054085..31061210 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276203.1 → NP_001263132.1 discs overgrown, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263132.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3P5, O76324, Q0KHY4, Q9V462

UniProtKB/TrEMBL

A0A0B4KHX3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_170535.2 → NP_733414.1 discs overgrown, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733414.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3P5, O76324, Q0KHY4, Q9V462

UniProtKB/TrEMBL

A0A0B4KHX3

Related

FBpp0085104

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_170536.3 → NP_733415.1 discs overgrown, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3P5, O76324, Q0KHY4, Q9V462

UniProtKB/TrEMBL

A0A0B4KHX3

Related

FBpp0085105

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_079863.3 → NP_524602.1 discs overgrown, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524602.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3P5, O76324, Q0KHY4, Q9V462

UniProtKB/TrEMBL

A0A0B4KHX3

Related

FBpp0085106

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
NM_001369991.1 → NP_001356928.1 discs overgrown, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3P5, O76324, Q0KHY4, Q9V462

UniProtKB/TrEMBL

A0A0B4KHX3

Conserved Domains (1) summary

cd14125
Location:8 → 282

STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon