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mesh mesh [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43688, updated on 4-Jan-2025

Summary

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Official Symbol
meshprovided by FlyBase
Official Full Name
meshprovided by FlyBase
Primary source
FLYBASE:FBgn0051004
Locus tag
Dmel_CG31004
See related
AllianceGenome:FB:FBgn0051004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.233; CG12074; CG15560; CG31004; CT5150; Dmel\CG31004; DmMesh; Mesh
Summary
Involved in smooth septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in Malpighian tubule; adult head; and gut section. Orthologous to human SUSD2 (sushi domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mesh in Genome Data Viewer
Location:
100B5-100B5; 3-102 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31178389..31195762, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27004111..27021484, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43458 Neighboring gene Guanylyl cyclase beta-subunit at 100B Neighboring gene slow termination of phototransduction Neighboring gene bottleneck Neighboring gene uncharacterized protein Neighboring gene chaoptin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila. Izumi Y, et al. J Cell Sci, 2019 Sep 26. PMID 31444286
  2. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Beyenbach KW, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267718, Free PMC Article
  3. Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut. MacMillan HA, et al. Sci Rep, 2017 Aug 18. PMID 28821771, Free PMC Article
  4. The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut. Izumi Y, et al. J Cell Sci, 2021 Mar 26. PMID 33589496
  5. The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning. Tan QH, et al. Cells, 2024 Feb 20. PMID 38474329, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
    Title: The Snakeskin-Mesh Complex of Smooth Septate Junction Restricts Yorkie to Regulate Intestinal Homeostasis in Drosophila.
  2. Mesh has a role in the developmental maturation of the Drosophila Malpighian tubule and in ion transport in the adult tubule.
    Title: The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in the Drosophila Malpighian tubule.
  3. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for smooth septate junctions (sSJs) formation, as well as intestinal barrier function.
    Title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in smooth septate junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mesh
Names
CG31004-PA
CG31004-PB
CG31004-PC
CG31004-PD
CG31004-PE
mesh-PA
mesh-PB
mesh-PC
mesh-PD
mesh-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31178389..31195762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170310.1 → NP_001163781.1  mesh, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHZ4
    Conserved Domains (5) summary
    smart00032
    Location:1121 → 1171
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00216
    Location:811 → 999
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:259 → 419
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam01833
    Location:446 → 511
    TIG; IPT/TIG domain
    pfam03782
    Location:660 → 805
    AMOP; AMOP domain

  2. NM_001300689.1 → NP_001287618.1  mesh, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHZ4
    Conserved Domains (5) summary
    smart00032
    Location:1121 → 1171
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00216
    Location:811 → 999
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:259 → 419
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam01833
    Location:446 → 511
    TIG; IPT/TIG domain
    pfam03782
    Location:660 → 805
    AMOP; AMOP domain

  3. NM_170540.1 → NP_733419.1  mesh, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733419.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHY3
    Related
    FBpp0085141, FBtr0085780
    Conserved Domains (4) summary
    smart00032
    Location:1121 → 1171
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00216
    Location:811 → 999
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:259 → 419
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam03782
    Location:660 → 805
    AMOP; AMOP domain

  4. NM_170539.1 → NP_733418.1  mesh, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHY3
    Related
    FBpp0085140, FBtr0085779
    Conserved Domains (4) summary
    smart00032
    Location:1121 → 1171
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00216
    Location:811 → 999
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:259 → 419
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam03782
    Location:660 → 805
    AMOP; AMOP domain

  5. NM_001170311.1 → NP_001163782.1  mesh, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3DNA3, E1JJ26, E1JJ27, E2QD49, Q0KHY3, Q6NND0, Q8MR59
    Conserved Domains (4) summary
    smart00032
    Location:1121 → 1171
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00216
    Location:811 → 999
    VWD; von Willebrand factor (vWF) type D domain
    smart00539
    Location:259 → 419
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    pfam03782
    Location:660 → 805
    AMOP; AMOP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHZ4 A0A0B4LHZ4
Q0KHY3.2 Q0KHY3

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