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ATPsynC ATP synthase, subunit C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43693, updated on 4-Jan-2025

Summary

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Official Symbol
ATPsynCprovided by FlyBase
Official Full Name
ATP synthase, subunit Cprovided by FlyBase
Primary source
FLYBASE:FBgn0039830
Locus tag
Dmel_CG1746
See related
AllianceGenome:FB:FBgn0039830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey224; AT91; Atp5g1; ATP5MC3; CG1746; dATPsynC; Dmel\CG1746
Summary
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and larval muscle cell. Used to study early-onset dystonia and/or spastic paraplegia and mitochondrial complex V (ATP synthase) deficiency. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia; renal cell carcinoma; and urinary bladder cancer. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); ATP5MC2 (ATP synthase membrane subunit c locus 2); and ATP5MC3 (ATP synthase membrane subunit c locus 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ATPsynC in Genome Data Viewer
Location:
100B7-100B7; 3-102 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31216145..31219630, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27041867..27045352, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene zwilch Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P RNA Neighboring gene mir-4949 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Drosophila ATPsynC mutants as a new model of mitochondrial ATP synthase disorders. Lovero D, et al. PLoS One, 2018. PMID 30096161, Free PMC Article
  2. A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia. Neilson DE, et al. Mov Disord, 2022 Feb. PMID 34636445, Free PMC Article
  3. Transcriptional control of an essential ribozyme in Drosophila reveals an ancient evolutionary divide in animals. Manivannan SN, et al. PLoS Genet, 2015 Jan. PMID 25569672, Free PMC Article
  4. ATP synthase is required for male fertility and germ cell maturation in Drosophila testes. Yu J, et al. Mol Med Rep, 2019 Mar. PMID 30628672, Free PMC Article
  5. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber T, et al. Nature, 2019 Jun. PMID 31092924, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP synthase, subunit C
Names
ATP synthase Lipid-binding protein P1
ATP synthase lipid-binding protein
ATPsynC-PA
ATPsynC-PB
ATPsynC-PC
ATPsynC-PE
ATPsynC-PG
ATPsynthaseC
CG1746-PA
CG1746-PB
CG1746-PC
CG1746-PE
CG1746-PG
F0/F1 ATP synthase Lipid-binding protein
complex Vc

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31216145..31219630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143595.2 → NP_651852.1  ATP synthase, subunit C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651852.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNC4, Q6NN09
    Related
    FBpp0085134
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 138
    ATP9; ATP synthase F0 subunit 9; Provisional

  2. NM_001260453.1 → NP_001247382.1  ATP synthase, subunit C, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNC4, Q6NN09
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 138
    ATP9; ATP synthase F0 subunit 9; Provisional

  3. NM_170544.2 → NP_733423.1  ATP synthase, subunit C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNC4, Q6NN09
    Related
    FBpp0085135
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 138
    ATP9; ATP synthase F0 subunit 9; Provisional

  4. NM_170543.3 → NP_733422.1  ATP synthase, subunit C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733422.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNC4, Q6NN09
    Related
    FBpp0085136
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 138
    ATP9; ATP synthase F0 subunit 9; Provisional

  5. NM_001260455.2 → NP_001247384.1  ATP synthase, subunit C, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H0RNC4, Q6NN09
    Conserved Domains (1) summary
    MTH00222
    Location:62 → 138
    ATP9; ATP synthase F0 subunit 9; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H0RNC4 H0RNC4
Q6NN09 Q6NN09

Gene LinkOut

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