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spn-F spn-F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43700, updated on 9-Dec-2024

Summary

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Official Symbol
spn-Fprovided by FlyBase
Official Full Name
spn-Fprovided by FlyBase
Primary source
FLYBASE:FBgn0086362
Locus tag
Dmel_CG12114
See related
AllianceGenome:FB:FBgn0086362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1130/03; CG12114; Dmel\CG12114; l(3)S113003b; Spn-F; SpnF
Summary
Involved in several processes, including chaeta morphogenesis; oocyte axis specification; and positive regulation of neuron remodeling. Located in Golgi apparatus. Is expressed in macrochaeta and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See spn-F in Genome Data Viewer
Location:
100B8-100B9; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31255127..31256659)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27080849..27082381)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qless Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 6 Neighboring gene Carbonic anhydrase 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis. Dubin-Bar D, et al. BMC Cell Biol, 2008 Sep 17. PMID 18796167, Free PMC Article
  2. Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons. Lin T, et al. PLoS Genet, 2020 Feb. PMID 32059017, Free PMC Article
  3. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Amsalem S, et al. Mol Cell Biol, 2013 Nov. PMID 24019068, Free PMC Article
  4. The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity. Baskar R, et al. FEBS J, 2019 Oct. PMID 31152621
  5. Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. Bitan A, et al. Mol Cell Biol, 2010 Jan. PMID 19917727, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings reveal a novel regulatory mechanism for dendrite pruning achieved by temporal activation of Ik2 kinase and dynein-mediated redistribution of Ik2/Spn-F complex in neurons
    Title: Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons.
  2. These results suggest that polarized transport and selective retention regulate the distal tip localization of the Spn-F-IKKepsilon complex during bristle cell elongation.
    Title: A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation.
  3. Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity.
    Title: Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.
  4. Spn-F and Ik2 are localized to the bristle tip and that mutations in ik2 and spn-F affect bristle microtubules and actin organization
    Title: Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle.
  5. IkappaB kinase 2 binds physically to Spindle-F protein, biomolecular interaction analysis of Spindle-F protein and IkappaB kinase 2 demonstrating that both proteins bind directly and form a complex
    Title: The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton polarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of pole plasm oskar mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spn-F
Names
CG12114-PA
CG12114-PB
Spindle-F
lethal (3) S113003b
spindle F
spn-F-PA
spn-F-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31255127..31256659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143601.3 → NP_651858.1  spn-F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651858.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9Y9
    Related
    FBpp0085122

  2. NM_001276209.1 → NP_001263138.1  spn-F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI68
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KI68 A0A0B4KI68
Q9V9Y9.1 Q9V9Y9

Gene LinkOut

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