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PNPase - Polynucleotide phosphorylase

Predicted to enable 3'-5'-RNA exonuclease activity and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrial mRNA polyadenylation; and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval central nervous system; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70; combined oxidative phosphorylation deficiency 13; and spinocerebellar ataxia type 25. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to PNPase

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Species Gene Architecture aa