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PNPase Polynucleotide phosphorylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43710, updated on 27-Dec-2024

Summary

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Official Symbol
PNPaseprovided by FlyBase
Official Full Name
Polynucleotide phosphorylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0039846
Locus tag
Dmel_CG11337
See related
AllianceGenome:FB:FBgn0039846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11337; Dmel\CG11337; dmpnpase
Summary
Predicted to enable 3'-5'-RNA exonuclease activity and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrial mRNA polyadenylation; and regulation of mitochondrial mRNA stability. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval central nervous system; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70; combined oxidative phosphorylation deficiency 13; and spinocerebellar ataxia type 25. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PNPase in Genome Data Viewer
Location:
100C3-100C3; 3-102 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31401560..31405452, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27227282..27231174, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 35 member D1 Neighboring gene Gcn2 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene uncharacterized protein Neighboring gene Lysyl oxidase-like 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUV3 helicase is required for correct processing of mitochondrial transcripts. Clemente P, et al. Nucleic Acids Res, 2015 Sep 3. PMID 26152302, Free PMC Article
  2. Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. Pajak A, et al. PLoS Genet, 2019 Jul. PMID 31365523, Free PMC Article
  3. G protein-coupled receptor kinase 2 is required for rhythmic olfactory responses in Drosophila. Tanoue S, et al. Curr Biol, 2008 Jun 3. PMID 18499458, Free PMC Article
  4. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Molnar C, et al. Proc Natl Acad Sci U S A, 2007 May 8. PMID 17483466, Free PMC Article
  5. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Cheng S, et al. Dev Biol, 2010 Jan 1. PMID 19850026, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyribonucleotide nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyribonucleotide nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial RNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polynucleotide phosphorylase
Names
CG11337-PA
CG11337-PB
CG11337-PD
CG11337-PE
PNPase-PA
PNPase-PB
PNPase-PD
PNPase-PE
NP_001097990.2
NP_001163783.1
NP_651867.2
NP_733429.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31401560..31405452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170312.1 → NP_001163783.1  polynucleotide phosphorylase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163783.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRH9, Q5U1D1, Q9V9X7
    Conserved Domains (1) summary
    PRK11824
    Location:42 → 751
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

  2. NM_170550.2 → NP_733429.1  polynucleotide phosphorylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733429.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRH9, Q5U1D1, Q9V9X7
    Related
    FBpp0085172
    Conserved Domains (1) summary
    PRK11824
    Location:42 → 751
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

  3. NM_001104520.3 → NP_001097990.2  polynucleotide phosphorylase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097990.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRH9, Q5U1D1, Q9V9X7
    Conserved Domains (1) summary
    PRK11824
    Location:42 → 751
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional

  4. NM_143610.3 → NP_651867.2  polynucleotide phosphorylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651867.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRH9, Q5U1D1, Q9V9X7
    Related
    FBpp0085173
    Conserved Domains (1) summary
    PRK11824
    Location:42 → 751
    PRK11824; polynucleotide phosphorylase/polyadenylase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U1D1 Q5U1D1
Q8IH29 Q8IH29
Q95RX7 Q95RX7
Q9V9X7 Q9V9X7

Gene LinkOut

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