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CycG Cyclin G [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43724, updated on 9-Dec-2024

Summary

Official Symbol
CycGprovided by FlyBase
Official Full Name
Cyclin Gprovided by FlyBase
Primary source
FLYBASE:FBgn0039858
Locus tag
Dmel_CG11525
See related
AllianceGenome:FB:FBgn0039858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.25; anon-EST:Liang-2.24; CG 11525; CG11525; chr3R:27424276..27424475; clone 1.25; clone 2.24; cycG; dCycG; Dmel\CG11525; i205; i261
Summary
Enables protein phosphatase inhibitor activity. Involved in several processes, including DNA repair; negative regulation of G1/S transition of mitotic cell cycle; and regulation of signal transduction. Located in polytene chromosome. Is expressed in germarium region 2 and oocyte. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to human CCNG1 (cyclin G1) and CCNG2 (cyclin G2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See CycG in Genome Data Viewer
Location:
100C7-100C7; 3-102 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31596642..31612664, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27422364..27438386, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L6 Neighboring gene Medea Neighboring gene microtubule-associated Nat9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein phosphatase inhibitor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin G
Names
CG11525-PA
CG11525-PB
CG11525-PC
CG11525-PD
CG11525-PF
CycG-PA
CycG-PB
CycG-PC
CycG-PD
CycG-PF
cyclin G1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31596642..31612664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276217.2NP_001263146.1  cyclin G, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263146.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TJ9
    Conserved Domains (1) summary
    cl00050
    Location:287365
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. NM_170557.3NP_733436.1  cyclin G, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733436.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TJ9
    Related
    FBpp0085160
    Conserved Domains (1) summary
    cl00050
    Location:287365
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  3. NM_079870.4NP_524609.2  cyclin G, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524609.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TJ9
    Related
    FBpp0085161
    Conserved Domains (1) summary
    cl00050
    Location:287365
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  4. NM_170555.3NP_733434.1  cyclin G, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733434.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TJ9
    Related
    FBpp0085163
    Conserved Domains (1) summary
    cl00050
    Location:287365
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  5. NM_170556.3NP_733435.1  cyclin G, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95TJ9
    Related
    FBpp0085164
    Conserved Domains (1) summary
    cl00050
    Location:287365
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...