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Mnat9 microtubule-associated Nat9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43726, updated on 9-Dec-2024

Summary

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Official Symbol
Mnat9provided by FlyBase
Official Full Name
microtubule-associated Nat9provided by FlyBase
Primary source
FLYBASE:FBgn0039859
Locus tag
Dmel_CG11539
See related
AllianceGenome:FB:FBgn0039859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11539; Dmel\CG11539; NAT9
Summary
Enables microtubule binding activity. Involved in negative regulation of intracellular signal transduction and regulation of microtubule cytoskeleton organization. Orthologous to human NAT9 (N-acetyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mnat9 in Genome Data Viewer
Location:
100D1-100D1; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31615284..31616160, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27441006..27441882, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L6 Neighboring gene Cyclin G Neighboring gene Medea Neighboring gene uncharacterized protein Neighboring gene partner of drosha Neighboring gene kekkon 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeted recombination of homologous chromosomes using CRISPR-Cas9. Son W, et al. FEBS Open Bio, 2023 Sep. PMID 37462508, Free PMC Article
  2. Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila. Mok JW, et al. Cell Death Dis, 2022 Feb 2. PMID 35110540, Free PMC Article
  3. N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye. Deshpande P, et al. Cell Death Dis, 2023 Jul 28. PMID 37507384, Free PMC Article
  4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
  5. Global and specific responses of the histone acetylome to systematic perturbation. Feller C, et al. Mol Cell, 2015 Feb 5. PMID 25578876

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye.
    Title: N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye.
  2. Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.
    Title: Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin N-terminal N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated Nat9
Names
CG11539-PA
CG11539-PB
Mnat9-PA
Mnat9-PB
NP_001263148.1
NP_651877.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31615284..31616160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276219.1 → NP_001263148.1  microtubule-associated Nat9, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263148.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9V9
    UniProtKB/TrEMBL
    A0A0B4KHX9
    Conserved Domains (2) summary
    pfam00583
    Location:76 → 160
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam13302
    Location:13 → 158
    Acetyltransf_3; Acetyltransferase (GNAT) domain

  2. NM_143620.2 → NP_651877.1  microtubule-associated Nat9, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651877.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9V9
    UniProtKB/TrEMBL
    A0A0B4KHX9
    Related
    FBpp0085227
    Conserved Domains (2) summary
    pfam00583
    Location:76 → 160
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam13302
    Location:13 → 158
    Acetyltransf_3; Acetyltransferase (GNAT) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHX9 A0A0B4KHX9
Q9V9V9.1 Q9V9V9

Gene LinkOut

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