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Ank Ankyrin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43770, updated on 2-Nov-2024

Summary

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Official Symbol
Ankprovided by FlyBase
Official Full Name
Ankyrinprovided by FlyBase
Primary source
FLYBASE:FBgn0011747
Locus tag
Dmel_CG1651
See related
AllianceGenome:FB:FBgn0011747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ank; ANK; CG1651; CG32008; dank1; Dank1; DAnk1; Dmel\CG1651
Summary
Predicted to enable cytoskeletal anchor activity; spectrin binding activity; and transmembrane transporter binding activity. Predicted to be involved in protein localization to plasma membrane. Located in plasma membrane and spectrosome. Is expressed in several structures, including adult head; adult heart; germline stem cell; ovary; and salivary gland body primordium. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Ank in Genome Data Viewer
Location:
102A3-102A3; 4-0 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (115074..129849, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (135700..150475, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S3A Neighboring gene pangolin Neighboring gene long non-coding RNA:CR43956 Neighboring gene anne boleyn Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ankyrin and beta-spectrin accumulate independently of alpha-spectrin in Drosophila. Dubreuil RR, et al. Proc Natl Acad Sci U S A, 1994 Oct 25. PMID 7937942, Free PMC Article
  2. Patterns of genetic variation at a chromosome 4 locus of Drosophila melanogaster and D. simulans. Jensen MA, et al. Genetics, 2002 Feb. PMID 11861556, Free PMC Article
  3. Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. Malhotra JD, et al. J Biol Chem, 2000 Apr 14. PMID 10753953
  4. Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. Dubreuil RR, et al. J Cell Biol, 1996 May. PMID 8636238, Free PMC Article
  5. A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly. Hortsch M, et al. Cell Adhes Commun, 1998 Jan. PMID 9638342

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, use of osmolyte cosolvents demonstrates that hydrogen-bonding contributions can be separated from hydrophobic interactions in the denatured state of a truncated notch ankyrin protein domain.
    Title: Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes.
  2. Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/Ank/microtubule cytoskeleton are reported.
    Title: Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton.
  3. the Spectrin network is playing a role independently of Ankyrin in the establishment and/or maintenance of specialized membrane domains containing guidance molecules that ensure the fidelity of axon repulsion at the midline
    Title: beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c119039-118965 mobile_element_type = transposon:INE-1{}4171
  • Loc: c126666-125492 mobile_element_type = transposon:Tc1{}1485
  • Loc: c128439-128086 mobile_element_type = transposon:S2{}1486
  • Loc: c128824-127987 mobile_element_type = transposon:INE-1{}4640
  • Loc: c129057-128965 mobile_element_type = transposon:INE-1{}4643

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spectrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spectrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin
Names
Ank-PB
Ank-PC
Ank-PD
Ank-PE
Ank1
CG1651-PB
CG1651-PC
CG1651-PD
CG1651-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    115074..129849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169348.2 → NP_001162819.1  ankyrin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]

  2. NM_175927.3 → NP_787123.1  ankyrin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088238
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]

  3. NM_175928.3 → NP_787124.1  ankyrin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088239
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]

  4. NM_175926.3 → NP_787122.1  ankyrin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_787122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIE7, Q24241
    Related
    FBpp0088240
    Conserved Domains (7) summary
    smart00218
    Location:930 → 1034
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd00204
    Location:491 → 616
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd08317
    Location:1439 → 1521
    Death_ank; Death domain associated with Ankyrins
    pfam12796
    Location:633 → 723
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:300 → 353
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:582 → 636
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:496 → 527
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KIE7 Q0KIE7
Q24241 Q24241
Q95TU4 Q95TU4
Q95UF0 Q95UF0

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