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Arl4 ADP ribosylation factor-like 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43771, updated on 9-Dec-2024

Summary

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Official Symbol
Arl4provided by FlyBase
Official Full Name
ADP ribosylation factor-like 4provided by FlyBase
Primary source
FLYBASE:FBgn0039889
Locus tag
Dmel_CG2219
See related
AllianceGenome:FB:FBgn0039889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
arl4; ARL4B; BcDNA:AT26185; CG 2219; CG2219; Dmel\CG2219; Q9V4B2
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in cleavage furrow. Is expressed in organism. Orthologous to several human genes including ARL4A (ADP ribosylation factor like GTPase 4A) and ARL4C (ADP ribosylation factor like GTPase 4C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Arl4 in Genome Data Viewer
Location:
102A6-102A6; 4-0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (177348..179389, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (197974..200015, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45198 Neighboring gene long non-coding RNA:CR46488 Neighboring gene ATP binding cassette subfamily D member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PH Domain-Arf G Protein Interactions Localize the Arf-GEF Steppke for Cleavage Furrow Regulation in Drosophila. Lee DM, et al. PLoS One, 2015. PMID 26556630, Free PMC Article
  2. Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication. Pasqualato S, et al. EMBO Rep, 2002 Nov. PMID 12429613, Free PMC Article
  3. The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion. Armbruster K, et al. J Cell Sci, 2012 Mar 1. PMID 22349697
  4. Gene transposition as a cause of hybrid sterility in Drosophila. Masly JP, et al. Science, 2006 Sep 8. PMID 16960009
  5. The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Ryder E, et al. Genetics, 2004 Jun. PMID 15238529, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP ribosylation factor-like 4
Names
Arl4-PA
Arl4-PB
Arl4-PC
CG2219-PA
CG2219-PB
CG2219-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    177348..179389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258479.3 → NP_001245408.1  ADP ribosylation factor-like 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9XVM3
    Conserved Domains (1) summary
    cl21455
    Location:24 → 311
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001272118.1 → NP_001259047.1  ADP ribosylation factor-like 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MN60
    Conserved Domains (1) summary
    cl38936
    Location:22 → 95
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_143648.3 → NP_651905.1  ADP ribosylation factor-like 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V4B2
    Related
    FBpp0088220
    Conserved Domains (1) summary
    cd04152
    Location:22 → 310
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H9XVM3 H9XVM3
L0MN60 L0MN60
Q9V4B2 Q9V4B2

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