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Abcd1 ATP binding cassette subfamily D member 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43772, updated on 9-Dec-2024

Summary

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Official Symbol
Abcd1provided by FlyBase
Official Full Name
ATP binding cassette subfamily D member 1provided by FlyBase
Primary source
FLYBASE:FBgn0039890
Locus tag
Dmel_CG2316
See related
AllianceGenome:FB:FBgn0039890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ABCD; ABCD1/2; CG2316; dABCD; DmCG2316; Dmel\CG2316
Summary
Predicted to enable ABC-type fatty-acyl-CoA transporter activity; ATP binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in long-chain fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in adult head. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1) and ABCD2 (ATP binding cassette subfamily D member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Abcd1 in Genome Data Viewer
Location:
102A6-102A6; 4-0 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (184076..193829, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (204702..214455, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46488 Neighboring gene ADP ribosylation factor-like 4 Neighboring gene long non-coding RNA:CR44441 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Gordon HB, et al. Dis Model Mech, 2018 Jun 15. PMID 29739804, Free PMC Article
  2. SON protects nascent transcripts from unproductive degradation by counteracting DIP1. Tay ML, et al. PLoS Genet, 2019 Nov. PMID 31730657, Free PMC Article
  3. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Sun FL, et al. Mol Cell Biol, 2004 Sep. PMID 15340080, Free PMC Article
  4. Gene transposition as a cause of hybrid sterility in Drosophila. Masly JP, et al. Science, 2006 Sep 8. PMID 16960009
  5. Identification and characterization of a juvenile hormone response element and its binding proteins. Li Y, et al. J Biol Chem, 2007 Dec 28. PMID 17956872, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c185457-184965 mobile_element_type = transposon:INE-1{}4839
  • Loc: c193017-192640 mobile_element_type = transposon:INE-1{}4844

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type fatty-acyl-CoA transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid import into peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid import into peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ATP binding cassette subfamily D member 1
Names
ATP binding cassette subfamily D
ATP-binding cassette, subfamily D, member 1
Abcd1-PA
Abcd1-PB
Abcd1-PC
Abcd1-PD
Abcd1-PG
Abcd1-PH
CG2316-PA
CG2316-PB
CG2316-PC
CG2316-PD
CG2316-PG
CG2316-PH
NP_001245409.1
NP_651906.1
NP_726542.1
NP_726543.1
NP_726544.1
NP_726546.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    184076..193829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166736.4 → NP_726542.1  ATP binding cassette subfamily D member 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726542.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Related
    FBpp0088215
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

  2. NM_166738.3 → NP_726544.1  ATP binding cassette subfamily D member 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Related
    FBpp0088213
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

  3. NM_166737.3 → NP_726543.1  ATP binding cassette subfamily D member 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726543.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Related
    FBpp0088214
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

  4. NM_143649.3 → NP_651906.1  ATP binding cassette subfamily D member 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651906.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Related
    FBpp0088217
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

  5. NM_166740.2 → NP_726546.1  ATP binding cassette subfamily D member 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726546.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Related
    FBpp0088216
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

  6. NM_001258480.1 → NP_001245409.1  ATP binding cassette subfamily D member 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUN3
    Conserved Domains (1) summary
    TIGR00954
    Location:75 → 715
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JUN3.1 Q7JUN3

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