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Rad23 Rad23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43785, updated on 9-Dec-2024

Summary

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Official Symbol
Rad23provided by FlyBase
Official Full Name
Rad23provided by FlyBase
Primary source
FLYBASE:FBgn0026777
Locus tag
Dmel_CG1836
See related
AllianceGenome:FB:FBgn0026777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1836; DHR23; Dmel\CG1836; rad23; RAD23
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in nucleotide-excision repair and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in adult head and organism. Orthologous to several human genes including RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rad23 in Genome Data Viewer
Location:
102B3-102B3; 4-0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (308093..310822)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (328719..331448)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44023 Neighboring gene Synaptotagmin 7 Neighboring gene Zinc/iron regulated transporter-related protein 102B Neighboring gene Ring finger protein 11 Neighboring gene plasma membrane calcium ATPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Cloning and characterization of the homologue of the Saccharomyces cerevisiae gene in Drosophila melanogaster]. Nabirochkina EN, et al. Genetika, 1999 Jul. PMID 10519079
  2. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. Sutton JR, et al. Hum Mol Genet, 2017 Apr 15. PMID 28158474, Free PMC Article
  3. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
  4. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Blount JR, et al. Nat Commun, 2014 Aug 21. PMID 25144244, Free PMC Article
  5. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Additional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on the co-chaperone, DnaJ-1. Our data reveal a previously unrecognized balance between pathogenic and potentially therapeutic properties of the ataxin-3-Rad23 interaction; they highlight this interaction as critical for the toxicity of the S
    Title: Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
  2. Through DnaJ-1, our data connect ataxin-3 and Rad23 to protective processes involved with protein folding rather than increased turnover of toxic polyQ species.
    Title: The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Rad23
Names
CG1836-PA
CG1836-PB
CG1836-PC
Rad23-PA
Rad23-PB
Rad23-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    308093..310822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272123.1 → NP_001259052.1  Rad23, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3W9, Q9XZE0
    Conserved Domains (5) summary
    cd01805
    Location:1 → 76
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14378
    Location:153 → 199
    UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
    cd14427
    Location:371 → 411
    UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
    TIGR00601
    Location:1 → 413
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:242 → 296
    XPC-binding; XPC-binding domain

  2. NM_166752.2 → NP_726561.1  Rad23, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMB7, Q9XZE0
    Related
    FBpp0088190
    Conserved Domains (4) summary
    cd14378
    Location:82 → 128
    UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
    cd14427
    Location:300 → 340
    UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
    TIGR00601
    Location:1 → 342
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:171 → 225
    XPC-binding; XPC-binding domain

  3. NM_143661.3 → NP_651918.2  Rad23, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651918.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3W9, Q9XZE0
    Related
    FBpp0088191
    Conserved Domains (5) summary
    cd01805
    Location:1 → 76
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14378
    Location:153 → 199
    UBA1_Rhp23p_like; UBA1 domain of Schizosaccharomyces pombe UV excision repair protein Rhp23p and its homologs
    cd14427
    Location:371 → 411
    UBA2_HR23A; UBA2 domain of UV excision repair protein RAD23 homolog A (HR23A) found in vertebrates
    TIGR00601
    Location:1 → 413
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:242 → 296
    XPC-binding; XPC-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IMB7 Q8IMB7
Q9V3W9 Q9V3W9
Q9XZE0 Q9XZE0

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