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Eph - Eph receptor tyrosine kinase

Predicted to enable transmembrane-ephrin receptor activity. Involved in melanotic encapsulation of foreign target; mushroom body development; and peripheral nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; eye disc posterior to the morphogenetic furrow; larval central nervous system; neuron projection bundle of larval ventral nerve cord; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 88; cataract 6 multiple types; central conducting lymphatic anomaly; pancreatic cancer; and prostate cancer. Orthologous to several human genes including EPHA3 (EPH receptor A3); EPHA4 (EPH receptor A4); and EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa