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Slip1 SLo interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43809, updated on 9-Dec-2024

Summary

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Official Symbol
Slip1provided by FlyBase
Official Full Name
SLo interacting protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0024728
Locus tag
Dmel_CG1783
See related
AllianceGenome:FB:FBgn0024728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1783; Dmel\CG1783; dSLIP1
Summary
Enables potassium channel regulator activity. Is expressed in organism. Orthologous to several human genes including PDZRN4 (PDZ domain containing ring finger 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Slip1 in Genome Data Viewer
Location:
102D4-102D4; 4-0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (663621..669884)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (684247..690510)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene gawky Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene myoglianin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. Xia Xm, et al. J Neurosci, 1998 Apr 1. PMID 9502797, Free PMC Article
  2. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Wang W, et al. Science, 2002 Jan 4. PMID 11778050
  3. High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies. Sousa-Neves R, et al. Genetics, 2005 May. PMID 15466427, Free PMC Article
  4. Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors. Hall H, et al. BMC Neurosci, 2018 Jul 20. PMID 30029619, Free PMC Article
  5. Fourth Chromosome Resource Project: a comprehensive resource for genetic analysis in Drosophila that includes humanized stocks. Stinchfield MJ, et al. Genetics, 2024 Feb 7. PMID 37981656, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 667078-667195 mobile_element_type = transposon:INE-1{}1944
  • Loc: 667816-667929 mobile_element_type = transposon:INE-1{}1945

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
SLo interacting protein 1
Names
CG1783-PA
CG1783-PB
CG1783-PC
Slip1-PA
Slip1-PB
Slip1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    663621..669884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143676.2 → NP_651933.1  SLo interacting protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651933.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MR31, Q8STH5, Q9V4F2
    UniProtKB/TrEMBL
    F0JAN0
    Related
    FBpp0088159
    Conserved Domains (2) summary
    smart00228
    Location:11 → 47
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:219 → 276
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001272138.1 → NP_001259067.1  SLo interacting protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MN84
    Conserved Domains (2) summary
    smart00228
    Location:11 → 47
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:219 → 276
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. NM_001272137.1 → NP_001259066.1  SLo interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259066.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAN0, L0MPY6
    Conserved Domains (1) summary
    smart00228
    Location:11 → 47
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0MN84 L0MN84
L0MPY6 L0MPY6
Q8MR31.2 Q8MR31

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