ey eyeless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eyprovided by FlyBase
Official Full Name: eyelessprovided by FlyBase
Primary source: FLYBASE:FBgn0005558
Locus tag: Dmel_CG1464
See related: AllianceGenome:FB:FBgn0005558
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1464; Dmel\CG1464; DPax-6; Ey; EY; Ey/Pax6; eye; EYEL; l(4)102CDh; l(4)102CDr; l(4)33; OK107; Pax-6; pax6; Pax6; Pax6/ey
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adult walking behavior; nervous system development; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including intrinsic neurons; neuroblasts; neuromere; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102D4-102D5; 4-0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (697689..721173)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (718315..741799)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila.
Title: A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila.
changes in the temporal regulation of the highly conserved eyeless/Pax6 gene expression during development is a conserved mechanism for sensory trade-offs within and between Drosophila species.
Title: Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs.
We conclude that neurons with similar developmental origin have similar connectivity, that Eyeless maintains equal E-PG and P-EN neuron number, and that Eyeless is required for the development of circuits that control adult navigation.
Title: Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit.
Ey could use multiple molecular mechanisms to regulate target gene expression and pathway function, which might enable Ey to exhibit a greater flexibility in controlling different processes during eye development
Title: Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.
This study set Hipk and the master regulators Toy and Ey in an enzyme-substrate relationship. The interaction and phosphorylation of the master regulator Toy by Hipk may be important for precise tuning of signalling within the retinal determination gene network and therefore for Drosophila eye development.
Title: Homeodomain-interacting protein kinase phosphorylates the Drosophila Paired box protein 6 (Pax6) homologues Twin of eyeless and Eyeless.
Loss of Ey within the peripodial epithelium leads to the loss of dpp expression within the eye, failure of the furrow to initiate, and abrogation of retinal development. These findings reveal an unexpected mechanism for how Pax6 controls eye development in Drosophila.
Title: Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium.
The loss of Pax6, but not of Eya, is required for Sfmbt dependent eye-to-wing transformation.
Title: Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye.
Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila.
Title: Eyeless uncouples mushroom body neuroblast proliferation from dietary amino acids in Drosophila.
Pax6 initiates both eye specification and proliferation
Title: Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation.
Reducing levels of old intermediate neural progenitor (INP) temporal transcription factor Eyeless/Pax6 allows Notch signaling to promote dedifferentiation of INP progeny into ectopic INPs, creating a proliferative mass of ectopic progenitors in the brain.
Title: Aging Neural Progenitors Lose Competence to Respond to Mitogenic Notch Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 705995-706173 mobile_element_type = transposon:INE-1{}1957

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	TAS Traceable Author Statement more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: eyeless

Names: CG1464-PA; CG1464-PB; CG1464-PC; CG1464-PD; ey-PA; ey-PB; ey-PC; ey-PD; tumor-head-63

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

697689..721173

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166789.2 → NP_726607.1 eyeless, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726607.1

Status: REVIEWED

UniProtKB/TrEMBL

Q53XF9

Related

FBpp0088299

Conserved Domains (1) summary

pfam00046
Location:201 → 253

Homeobox; Homeobox domain
NM_001014693.2 → NP_001014693.1 eyeless, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014693.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18381, Q8ST91, Q8ST92, Q9V4F5

UniProtKB/TrEMBL

Q59DQ2

Conserved Domains (2) summary

smart00351
Location:98 → 221

PAX; Paired Box domain

pfam00046
Location:475 → 527

Homeobox; Homeobox domain
NM_079889.3 → NP_524628.2 eyeless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524628.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O18381, Q8ST91, Q8ST92, Q9V4F5

Related

FBpp0088300

Conserved Domains (2) summary

smart00351
Location:37 → 161

PAX; Paired Box domain

pfam00046
Location:415 → 467

Homeobox; Homeobox domain
NM_001014694.2 → NP_001014694.1 eyeless, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014694.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18381, Q8ST91, Q8ST92, Q9V4F5

UniProtKB/TrEMBL

Q59DQ1

Conserved Domains (2) summary

smart00351
Location:57 → 180

PAX; Paired Box domain

pfam00046
Location:434 → 486

Homeobox; Homeobox domain