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ey - eyeless

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adult walking behavior; nervous system development; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including intrinsic neurons; neuroblasts; neuromere; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa