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pho pleiohomeotic [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43819, updated on 2-Nov-2024

Summary

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Official Symbol
phoprovided by FlyBase
Official Full Name
pleiohomeoticprovided by FlyBase
Primary source
FLYBASE:FBgn0002521
Locus tag
Dmel_CG17743
See related
AllianceGenome:FB:FBgn0002521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17743; Dmel\CG17743; dYY1; l(4)102EFc; l(4)29; l(4)BU-2; l(4)OC-1; l(4)pho; Ph; Pho; PHO; PHO/YY1; YY1
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin DNA binding activity. Involved in several processes, including DNA topological change; dendrite morphogenesis; and regulation of gene expression. Located in chromatin; nucleus; and polytene chromosome puff. Part of Ino80 complex and PcG protein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to several human genes including YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pho in Genome Data Viewer
Location:
102F8-102F8; 4-0 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1172469..1181628, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1193095..1202254, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kinesin family member 3C Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol 5-phosphate 4-kinase Neighboring gene mitf

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue. Srinivasan L, et al. J Cell Biochem, 2005 Nov 1. PMID 16052488
  2. Novel embryonic and adult homeotic phenotypes are produced by pleiohomeotic mutations in Drosophila. Girton JR, et al. Dev Biol, 1994 Feb. PMID 8313991
  3. Prediction of Polycomb target genes in mouse embryonic stem cells. Liu Y, et al. Genomics, 2010 Jul. PMID 20353814
  4. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Wilkinson FH, et al. Proc Natl Acad Sci U S A, 2006 Dec 19. PMID 17158804, Free PMC Article
  5. Molecular Regulation of the Polycomb Repressive-Deubiquitinase. Reddington CJ, et al. Int J Mol Sci, 2020 Oct 22. PMID 33105797, Free PMC Article

See all (290) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.
    Title: Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila.
  2. Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
    Title: Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
  3. Mutation in the protein-protein interaction domain (REPO domain) of Pho interferes with the dynamics of its interaction with Spt5. The transcriptional kinetics of the heat shock response is negatively affected by a mutation in the REPO domain of Pho
    Title: Pho dynamically interacts with Spt5 to facilitate transcriptional switches at the hsp70 locus.
  4. Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho)
    Title: Pleiohomeotic interacts with the core transcription elongation factor Spt5 to regulate gene expression in Drosophila.
  5. even-skipped genes were misexpressed in pho mutant embryos
    Title: The pleiohomeotic functions as a negative regulator of Drosophila even-skipped gene during embryogenesis.
  6. The TF homolog pair Pho/Yy1 seems to play very different roles in PcG targeting between Drosophila and mouse.
    Title: Prediction of Polycomb target genes in mouse embryonic stem cells.
  7. CtBP regulates expression of intergenic transcripts that controls DNA binding by PcG proteins and subsequent histone modifications and transcriptional activity.
    Title: CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA.
  8. a DNA-binding complex requiring Pho is differentially regulated to facilitate epigenetic transcriptional memory of both the active and the repressed state
    Title: The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site.
  9. Pho is a general component of the maintenance machinery, since the majority of Pc targets are also associated with Pho (Pleiohomeotic )binding.
    Title: Stability and dynamics of polycomb target sites in Drosophila development.
  10. These results suggest that pho functions in maintaining expression of genes involved in the formation of ventral appendages and the proximo-distal axis.
    Title: The pleiohomeotic gene is required for maintaining expression of genes functioning in ventral appendage formation in Drosophila melanogaster.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c1173481-1173401 mobile_element_type = transposon:INE-1{}3960
  • Loc: c1177584-1176573 mobile_element_type = transposon:1360{}1561
  • Loc: c1178849-1175426 mobile_element_type = transposon:jockey2{}pho[1682]
  • Loc: c1179346-1179285 mobile_element_type = transposon:HB{}4574
  • Loc: c1179948-1179703 mobile_element_type = transposon:INE-1{}3961
  • Loc: c1180890-1180705 mobile_element_type = transposon:INE-1{}3963

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IC
Inferred by Curator
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome puff IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pleiohomeotic
Names
CG17743-PA
CG17743-PB
PHO
peiohomeotic
pho-PA
pho-PB
pleihomeotic
pleohomeotic
polyhomeotic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1172469..1181628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166827.2 → NP_726651.1  pleiohomeotic, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726651.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V138, O76247, Q6W466, Q6W467, Q6W470, Q6W480, Q6W485, Q8ST83, Q9V4A3
    Related
    FBpp0088269
    Conserved Domains (5) summary
    COG5048
    Location:386 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:388 → 408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:386 → 408
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:401 → 426
    zf-H2C2_2; Zinc-finger double domain
    pfam13963
    Location:342 → 382
    Transpos_assoc; Transposase-associated domain

  2. NM_079891.3 → NP_524630.1  pleiohomeotic, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524630.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V138, O76247, Q6W466, Q6W467, Q6W470, Q6W480, Q6W485, Q8ST83, Q9V4A3
    Related
    FBpp0088268
    Conserved Domains (5) summary
    COG5048
    Location:386 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:388 → 408
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:386 → 408
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:401 → 426
    zf-H2C2_2; Zinc-finger double domain
    pfam13963
    Location:342 → 382
    Transpos_assoc; Transposase-associated domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8ST83.2 Q8ST83

Gene LinkOut

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