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CaMKII Calcium/calmodulin-dependent protein kinase II [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43828, updated on 4-Jan-2025

Summary

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Official Symbol
CaMKIIprovided by FlyBase
Official Full Name
Calcium/calmodulin-dependent protein kinase IIprovided by FlyBase
Primary source
FLYBASE:FBgn0264607
Locus tag
Dmel_CG18069
See related
AllianceGenome:FB:FBgn0264607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ca2+/calmodulin-dependent protein kinase II; Calcium/calmodulin-dependent protein kinase; calcium/calmodulin-dependent protein kinase II; Cam; CaM; CaM II; CaM KII; CaM kinase; camk II; CaMK II; CamK-II; CaMK-II; camkii; camkII; camKII; Camkii; CamKII; CaMKii; CAMKII; CamKIIalpha; CAMKIIalpha; CAMKIId; CDPK1; CG18069; dCaMKII; dCAMKII; DCK; Dmel\CG18069; l(4)102EFb; l(4)16; l(4)ar
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including long-term memory; regulation of filopodium assembly; and regulation of synaptic assembly at neuromuscular junction. Acts upstream of with a positive effect on positive regulation of dopaminergic synaptic transmission. Located in several cellular components, including dendrite; postsynaptic membrane; and presynaptic active zone. Is expressed in several structures, including A1-7 ventral longitudinal muscle cell; adult brain; ganglia; midgut primordium; and synaptic neuropil domain. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 53; autosomal dominant intellectual developmental disorder 54; and autosomal recessive intellectual developmental disorder 63. Orthologous to several human genes including CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CaMKII in Genome Data Viewer
Location:
102F6-102F7; 4-0 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1035288..1053703, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1055914..1074329, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44031 Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Mitochondrial inner membrane protein MPV17 Neighboring gene Zyxin Neighboring gene apolipophorin Neighboring gene Activin-beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conditioning deficits of CaM-kinase transgenic Drosophila melanogaster in a new excitatory courtship assay. Broughton SJ, et al. J Neurogenet, 2003 Jan-Mar. PMID 14504030
  2. Pairing-Dependent Plasticity in a Dissected Fly Brain Is Input-Specific and Requires Synaptic CaMKII Enrichment and Nighttime Sleep. Adel M, et al. J Neurosci, 2022 May 25. PMID 35474278, Free PMC Article
  3. Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. Oka M, et al. J Biochem, 2017 Nov 1. PMID 28992057, Free PMC Article
  4. [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats]. Yabuki Y, et al. Yakugaku Zasshi, 2013. PMID 23649390
  5. Dynamic expression pattern of Ca(2+)/calmodulin-dependent protein kinase II gene in the central nervous system of Drosophila throughout development. Rachidi M, et al. Biochem Biophys Res Commun, 1999 Jul 14. PMID 10403830

See all (278) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
    Title: TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
  2. CaMKII may time a wide variety of behavioral and cognitive processes.
    Title: CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State.
  3. we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII
    Title: Synaptic Orb2A Bridges Memory Acquisition and Late Memory Consolidation in Drosophila.
  4. It is NMDA receptor downstream kinase and essential for memory and learning acquisition.(review)
    Title: [Imaging monitoring method of CaMKII activity by immunohistochemical analysis in schizophrenic model rats].
  5. these data support a model in which CaMKII-mediated synapsin phosphorylation in local circuit interneurons induces synaptic vesicle mobilization and thereby presynaptic facilitation of GABA release that underlies olfactory short-term habituation.
    Title: Synapsin function in GABA-ergic interneurons is required for short-term olfactory habituation.
  6. Regulated CaMKII autophosphorylation appears essential in central synapse development, and particular cholinergic synapses are affected differentially, although they operate via the same nicotinic receptor.
    Title: Constitutive activation of Ca2+/calmodulin-dependent protein kinase II during development impairs central cholinergic transmission in a circuit underlying escape behavior in Drosophila.
  7. These results suggest that presynaptic CaMKII activation depends on autophosphorylation and global Ca(2+) in the terminal, while translocation to AZs requires Ca(2+) microdomains generated by IP3Rs.
    Title: Differential control of presynaptic CaMKII activation and translocation to active zones.
  8. This study indicated a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections.
    Title: Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.
  9. We found that postsynaptic CaMKII regulates the localization of GluRIIA and GluRIIB, we hypothesize that postsynaptic CaMKII activity monitors the calcium influx through GluRIIA and regulate the amount of synaptic GluRIIA during larval stages
    Title: Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions.
  10. CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2
    Title: Role of Ca2+/calmodulin-dependent protein kinase II in Drosophila photoreceptors.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c1042714-1042174 mobile_element_type = transposon:INE-1{}3385
  • Loc: c1042985-1042789 mobile_element_type = transposon:INE-1{}3388
  • Loc: c1044309-1044162 mobile_element_type = transposon:INE-1{}3391
  • Loc: c1047067-1046766 mobile_element_type = transposon:INE-1{}3406
  • Loc: c1050149-1049729 mobile_element_type = transposon:INE-1{}3408
  • Loc: c1051956-1051622 mobile_element_type = transposon:INE-1{}3409

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in courtship behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning or memory NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_positive_effect positive regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ovulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calcium/calmodulin-dependent protein kinase II
Names
CG18069-PA
CG18069-PB
CG18069-PC
CG18069-PD
CG18069-PE
CG18069-PG
CG18069-PH
CG18069-PI
CG18069-PJ
CG18069-PK
CG18069-PL
CG18069-PM
Ca2+ calmodulin-dependent kinase II
Ca2+/calmodulin-dependent protein kinase II
CaM kinase
CaM kinase II
CaM-kinase-II
CaMKII-PA
CaMKII-PB
CaMKII-PC
CaMKII-PD
CaMKII-PE
CaMKII-PG
CaMKII-PH
CaMKII-PI
CaMKII-PJ
CaMKII-PK
CaMKII-PL
CaMKII-PM
Ca[2+]-calmodulin-dependent protein kinase II
Ca[2+]/calmodulin-dependent protein kinase II
Calcium/calmodulin-dependent protein kinase
Calcium/calmodulin-dependent protein kinase ii
calcium/ calmodulin-dependent protein kinase II
calcium/calmodulin-dependent protein kinase type II
calmodulin kinase II
calmodulin-dependent kinase
calmodulin-dependent protein kinase II
lethal (4) 102EFb
NP_001014696.1
NP_001162831.1
NP_001162832.1
NP_001162833.1
NP_001259082.1
NP_001259083.1
NP_001259084.1
NP_524635.3
NP_726633.2
NP_726634.1
NP_726635.2
NP_726636.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1035288..1053703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272153.1 → NP_001259082.1  Calcium/calmodulin-dependent protein kinase II, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259082.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MNA2
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:348 → 468
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. NM_079896.4 → NP_524635.3  Calcium/calmodulin-dependent protein kinase II, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524635.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V133
    Related
    FBpp0088281
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:349 → 476
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. NM_001272155.1 → NP_001259084.1  Calcium/calmodulin-dependent protein kinase II, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MLP2
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:370 → 490
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  4. NM_001272154.1 → NP_001259083.1  Calcium/calmodulin-dependent protein kinase II, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259083.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MLR4
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:388 → 508
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  5. NM_166813.3 → NP_726636.2  Calcium/calmodulin-dependent protein kinase II, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726636.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V134
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:368 → 495
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. NM_001014696.2 → NP_001014696.1  Calcium/calmodulin-dependent protein kinase II, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014696.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00168
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:375 → 502
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  7. NM_166812.3 → NP_726635.2  Calcium/calmodulin-dependent protein kinase II, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726635.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00168, Q59DP1, Q59DP2, Q9V495
    UniProtKB/TrEMBL
    D1YSG7
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:389 → 516
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  8. NM_166810.5 → NP_726633.2  Calcium/calmodulin-dependent protein kinase II, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726633.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V133
    Related
    FBpp0088282
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:349 → 476
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. NM_001169361.2 → NP_001162832.1  Calcium/calmodulin-dependent protein kinase II, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162832.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00168, Q59DP1, Q59DP2, Q9V495
    UniProtKB/TrEMBL
    D1YSG7
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:389 → 516
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  10. NM_166811.2 → NP_726634.1  Calcium/calmodulin-dependent protein kinase II, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726634.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V134
    Related
    FBpp0088283
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:368 → 495
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  11. NM_001169362.2 → NP_001162833.1  Calcium/calmodulin-dependent protein kinase II, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1YSG8
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:390 → 517
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  12. NM_001169360.2 → NP_001162831.1  Calcium/calmodulin-dependent protein kinase II, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V133
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:349 → 476
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V133 A4V133
A4V134 A4V134
D1YSG7 D1YSG7
D1YSG8 D1YSG8
L0MLP2 L0MLP2
L0MLR4 L0MLR4
L0MNA2 L0MNA2
Q00168.1 Q00168
Q24045 Q24045

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