fuss fussel [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fussprovided by FlyBase
Official Full Name: fusselprovided by FlyBase
Primary source: FLYBASE:FBgn0039932
Locus tag: Dmel_CG11093
See related: AllianceGenome:FB:FBgn0039932
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11093; CORL; dCORL; Dmel\CG11093
Summary: Enables co-SMAD binding activity. Involved in imaginal disc-derived wing vein specification and negative regulation of BMP signaling pathway. Located in cytosol. Is expressed in several structures, including bitter-sensitive labellar taste bristle; ganglia; gustatory receptor neurons; neuromere; and organism subdivision. Used to study nervous system disease. Orthologous to human SKOR1 (SKI family transcriptional corepressor 1) and SKOR2 (SKI family transcriptional corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102F4-102F4; 4-0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (962341..978489, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (982967..999115, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family.
Title: The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family.
Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity.
Title: Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity.
Our data show that mCORL2 and drosophila CORL share functions while mCORL1 has diverged which reinforces the current working hypothesis that neofunctionalization of a new gene can be achieved with a handful of advantageous amino acid changes in a highly conserved functional domain.
Title: Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.
Fuss interacts with Rpd3, and downregulation of rpd3 in gustatory neurons phenocopies the loss of Fuss expression. Surprisingly, there is no colocalization of Fuss with phosphorylated Mad in the larval central nervous system, excluding a direct involvement of Fuss in Dpp/BMP signaling.
Title: The Drosophila fussel gene is required for bitter gustatory neuron differentiation acting within an Rpd3 dependent chromatin modifying complex.
Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating.
Title: CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila.
Fuss exerts a pivotal role as an antagonist of BMP signaling in Drosophila melanogaster.[Fussel]
Title: fussel (fuss)--A negative regulator of BMP signaling in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c971521-971213 mobile_element_type = transposon:INE-1{}5452
Loc: c972906-972812 mobile_element_type = transposon:INE-1{}5451
Loc: c974320-974003 mobile_element_type = transposon:INE-1{}5440
Loc: c977670-977342 mobile_element_type = transposon:INE-1{}3305

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables co-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fussel

Names: CG11093-PB; CG11093-PC; CG11093-PD; CORL; fuss-PB; fuss-PC; fuss-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

962341..978489 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169358.2 → NP_001162829.1 fussel, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162829.1

Status: REVIEWED

UniProtKB/TrEMBL

D1YSG4

Conserved Domains (2) summary

smart01046
Location:135 → 228

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:25 → 123

Ski_Sno; SKI/SNO/DAC family
NM_001272150.2 → NP_001259079.1 fussel, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259079.1

Status: REVIEWED

UniProtKB/TrEMBL

D1YSG4

Conserved Domains (2) summary

smart01046
Location:135 → 228

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:25 → 123

Ski_Sno; SKI/SNO/DAC family
NM_001169359.1 → NP_001162830.1 fussel, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162830.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1RKX1

Conserved Domains (2) summary

smart01046
Location:129 → 222

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:26 → 117

Ski_Sno; SKI/SNO/DAC family