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unc-13 - unc-13

Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle tethering involved in synaptic vesicle exocytosis. Located in postsynaptic membrane; presynaptic active zone; and terminal bouton. Is expressed in several structures, including adult head; embryonic/larval neuromuscular junction; ganglia; presumptive embryonic/larval system; and spermatozoon. Used to study alcohol use disorder and epilepsy. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to several human genes including UNC13C (unc-13 homolog C). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa