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ras raspberry [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43873, updated on 9-Dec-2024

Summary

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Official Symbol
rasprovided by FlyBase
Official Full Name
raspberryprovided by FlyBase
Primary source
FLYBASE:FBgn0003204
Locus tag
Dmel_CG1799
See related
AllianceGenome:FB:FBgn0003204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11485; CG1799; Dmel\CG1799; EP(X)1093; IMPdH; IMPDH; l(1)9Eb; l(1)G0002; l(1)G0056; l(1)G0098; l(1)G0127; l(1)G0238; l(1)G0351; l(1)G0380; l(1)G0388; l(1)G0391; l(1)G0436; l(1)G0482; LD02673; LD06825; Ras; ras-l; raspberry/impd
Summary
Predicted to enable IMP dehydrogenase activity. Involved in axon guidance. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gonad; and mesoderm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ras in Genome Data Viewer
Location:
9E1-9E2; 1-32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10744502..10749097)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10638535..10643130)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene X11Lbeta Neighboring gene Rab at 9E Neighboring gene uncharacterized protein Neighboring gene stuxnet Neighboring gene long non-coding RNA:CR44766 Neighboring gene Rabphilin Neighboring gene Transport and Golgi organization 5 Neighboring gene Autophagy-related 8a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Temperature-sensitive mutations in Drosophila melanogaster. V. A mutation affecting concentrations of pteridines. Grigliatti T, et al. Proc Natl Acad Sci U S A, 1970 Nov. PMID 5274440, Free PMC Article
  2. The raspberry locus of Drosophila melanogaster includes an inosine monophosphate dehydrogenase like coding sequence. Nash D, et al. Genome, 1994 Apr. PMID 7911114
  3. Cloning and sequence analysis of a Drosophila melanogaster cDNA encoding IMP dehydrogenase. Sifri CD, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 7904480
  4. Genetic rescue of inviable hybrids between Drosophila melanogaster and its sibling species. Hutter P, et al. Nature, 1987 May 28-Jun 3. PMID 3108667
  5. A genetic basis for the inviability of hybrids between sibling species of Drosophila. Hutter P, et al. Genetics, 1990 Apr. PMID 2108905, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue-autonomous immune response regulates stress signaling during hypertrophy.
    Title: Tissue-autonomous immune response regulates stress signaling during hypertrophy.
  2. EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
    Title: EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.
  3. Ras-Dsor1 activity is independent of upstream activation by EGFR, and instead it appears to be activated by the insulin-like growth factor receptor to promote Wg signaling.
    Title: Ras-activated Dsor1 promotes Wnt signaling in Drosophila development.
  4. Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi
    Title: The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster.
  5. Loss-of-function mutations in dPLZF resulted in a dramatic suppression of the extra and ectopic vein formation induced by elevated Ras/ERK signaling.
    Title: The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development.
  6. Data show that inosine monophosphate dehydrogenase (IMPDH) binds sequence specifically to single-stranded, CT-rich DNA elements.
    Title: Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state.
  7. Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling.
    Title: Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells.
  8. Constitutive coactivation of EGFR-Ras and PI3K pathways in glia and glial precursors gives rise to neoplastic, invasive glial cells.
    Title: A drosophila model for EGFR-Ras and PI3K-dependent human glioma.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables IMP dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
raspberry
Names
CG1799-PA
CG1799-PC
CG1799-PD
CG1799-PE
CG1799-PF
IMP dehydrogenase
inosine monophosphate dehydrogenase
lethal (1) G0380
ras-PA
ras-PC
ras-PD
ras-PE
ras-PF
raspberry-lethal
NP_001259427.1
NP_001356940.1
NP_524646.5
NP_727441.1
NP_727442.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10744502..10749097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272498.2 → NP_001259427.1  raspberry, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07152, Q26455, Q8SXM5, Q9W2R8
    UniProtKB/TrEMBL
    A4V488
    Conserved Domains (3) summary
    cd00381
    Location:51 → 505
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:137 → 249
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:38 → 533
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  2. NM_167240.3 → NP_727441.1  raspberry, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727441.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07152, Q26455, Q8SXM5, Q9W2R8
    UniProtKB/TrEMBL
    A4V488
    Related
    FBpp0071424
    Conserved Domains (3) summary
    cd00381
    Location:51 → 505
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:137 → 249
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:38 → 533
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  3. NM_001369990.1 → NP_001356940.1  raspberry, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K3W6
    Conserved Domains (1) summary
    PTZ00314
    Location:38 → 533
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  4. NM_079907.7 → NP_524646.5  raspberry, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524646.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07152, Q26455, Q8SXM5, Q9W2R8
    UniProtKB/TrEMBL
    A4V488
    Conserved Domains (3) summary
    cd00381
    Location:51 → 505
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:137 → 249
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:38 → 533
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  5. NM_167241.3 → NP_727442.1  raspberry, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07152, Q26455, Q8SXM5, Q9W2R8
    UniProtKB/TrEMBL
    A4V488
    Related
    FBpp0071423
    Conserved Domains (3) summary
    cd00381
    Location:51 → 505
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:137 → 249
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:38 → 533
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K3W6 A0A4D6K3W6
A4V488 A4V488
Q07152.1 Q07152

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